| Mycophenolate in dermatology. | |
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MedLine Citation:
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PMID: 14660264 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Originally used to treat psoriasis nearly three decades ago, mycophenolic acid, reformulated as mycophenolate mofetil (MMF), has been rediscovered by the world of dermatology. As a relatively well-tolerated immunosuppressive used in organ transplant recipients, MMF has recently been reported to show promise for several dermatologic conditions, including psoriasis, pemphigus vulgaris, pyoderma gangrenosum, bullous lichen planus, and even connective tissue diseases such as lupus erythematosus and dermatomyositis. Although not intended to be exhaustive, this review discusses MMF with regard to its basic pharmacology, its side effects, and its reported efficacy in a variety of dermatologic indications. Relevant literature was retrieved by a Medline search combining the terms "mycophenolate" or "mycophenolic acid" and "skin" or "skin disease" or a number of specific conditions ("psoriasis", "dermatitis", "eczema", "pemphigoid", "pemphigus", "vasculitis", "pyoderma gangrenosum", "Crohn's disease", "graft-versus-host disease", "lichen planus"). As MMF has only been recently re-introduced for dermatologic application, the nature of much of the literature is admittedly that of case reports or case series. Nevertheless, the results are sufficiently promising to warrant further larger, control studies. |
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Authors:
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V Liu; B T Mackool |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: The Journal of dermatological treatment Volume: 14 ISSN: 0954-6634 ISO Abbreviation: J Dermatolog Treat Publication Date: 2003 Dec |
Date Detail:
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Created Date: 2003-12-08 Completed Date: 2004-01-15 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8918133 Medline TA: J Dermatolog Treat Country: England |
Other Details:
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Languages: eng Pagination: 203-11 Citation Subset: IM |
Affiliation:
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Department of Dermatology, Harvard Medical School, Massachusetts General Hospital Dermatopathology Unit, 55 Fruit Street, Boston, MA 02114, USA. bmackool@partners.org |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Dose-Response Relationship, Drug Drug Administration Schedule Eczema / drug therapy Female Graft vs Host Disease Humans Lichen Planus / drug therapy Male Mycophenolic Acid / adverse effects, analogs & derivatives*, pharmacology, therapeutic use* Pregnancy Psoriasis / drug therapy Pyoderma Gangrenosum / drug therapy Randomized Controlled Trials as Topic Risk Assessment Skin Diseases / diagnosis*, drug therapy* Skin Diseases, Vesiculobullous / drug therapy Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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128794-94-5/mycophenolate mofetil; 24280-93-1/Mycophenolic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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