Document Detail


Is Mycobacterium tuberculosis stressed out? A critical assessment of the genetic evidence.
MedLine Citation:
PMID:  20691805     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mycobacterium tuberculosis is an obligate human intracellular pathogen which remains a major killer worldwide. A remarkable feature of M. tuberculosis infection is the ability of the pathogen to persist within the host for decades despite an impressive onslaught of stresses. In this review we seek to outline the host-inflicted stresses experienced by M. tuberculosis, the bacterial strategies used to withstand these stresses, and how this information should guide our efforts to combat this global pathogen.
Authors:
Christina L Stallings; Michael S Glickman
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Review     Date:  2010-08-05
Journal Detail:
Title:  Microbes and infection / Institut Pasteur     Volume:  12     ISSN:  1769-714X     ISO Abbreviation:  Microbes Infect.     Publication Date:  2010 Dec 
Date Detail:
Created Date:  2010-12-07     Completed Date:  2011-03-10     Revised Date:  2013-04-16    
Medline Journal Info:
Nlm Unique ID:  100883508     Medline TA:  Microbes Infect     Country:  France    
Other Details:
Languages:  eng     Pagination:  1091-101     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Institut Pasteur. Published by Elsevier SAS. All rights reserved.
Affiliation:
Department of Molecular Microbiology, Washington University School of Medicine, St. Louis, MO 63110, USA.
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MeSH Terms
Descriptor/Qualifier:
Gene Expression Regulation, Bacterial*
Host-Pathogen Interactions
Humans
Mycobacterium tuberculosis / pathogenicity,  physiology*
Stress, Physiological*
Grant Support
ID/Acronym/Agency:
AI075805/AI/NIAID NIH HHS; AI53417/AI/NIAID NIH HHS; AI80628/AI/NIAID NIH HHS; R01 AI053417-09/AI/NIAID NIH HHS; R01 AI064693/AI/NIAID NIH HHS; R01 AI080628-01A1/AI/NIAID NIH HHS
Comments/Corrections

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