| Mycobacterium tuberculosis phagosome maturation arrest: selective targeting of PI3P-dependent membrane trafficking. | |
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MedLine Citation:
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PMID: 12911814 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The ability of Mycobacterium tuberculosis to enter host macrophages, and reside in a phagosome, which does not mature into a phagolysosome, is central to the spread of tuberculosis and the associated pandemic involving billions of people worldwide. Tuberculosis can be viewed as a disease with a significant intracellular trafficking and organellar biogenesis component. Current understanding of the block in M. tuberculosis phagosome maturation also sheds light on fundamental aspects of phagolysosome biogenesis. The maturation block involves interference with the recruitment and function of rabs, rab effectors (phosphatidylinositol 3-kinases and tethering molecules such as EEA1), SNAREs (Syntaxin 6 and cellubrevin) and Ca2+/calmodulin signaling. M. tuberculosis analogs of mammalian phosphatidylinositols interfere with these systems and associated processes. |
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Authors:
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Isabelle Vergne; Jennifer Chua; Vojo Deretic |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S.; Review |
Journal Detail:
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Title: Traffic (Copenhagen, Denmark) Volume: 4 ISSN: 1398-9219 ISO Abbreviation: Traffic Publication Date: 2003 Sep |
Date Detail:
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Created Date: 2003-08-12 Completed Date: 2004-05-24 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 100939340 Medline TA: Traffic Country: Denmark |
Other Details:
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Languages: eng Pagination: 600-6 Citation Subset: IM |
Affiliation:
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Department of Molecular Genetics and Microbiology, University of New Mexico Medical School, Albuquerque, NM 87131, USA. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biological Markers / chemistry Biological Transport Calcium / physiology Calmodulin / physiology Cell Membrane / metabolism Humans Mycobacterium tuberculosis / metabolism, pathogenicity*, physiology Phagosomes / metabolism, microbiology* Phosphatidylinositol Phosphates / physiology* |
| Grant Support | |
ID/Acronym/Agency:
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AI 42999/AI/NIAID NIH HHS; AI 45148/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Biological Markers; 0/Calmodulin; 0/Phosphatidylinositol Phosphates; 0/phosphatidylinositol 3-phosphate; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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