Document Detail


Mycobacterium tuberculosis phagosome maturation arrest: selective targeting of PI3P-dependent membrane trafficking.
MedLine Citation:
PMID:  12911814     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The ability of Mycobacterium tuberculosis to enter host macrophages, and reside in a phagosome, which does not mature into a phagolysosome, is central to the spread of tuberculosis and the associated pandemic involving billions of people worldwide. Tuberculosis can be viewed as a disease with a significant intracellular trafficking and organellar biogenesis component. Current understanding of the block in M. tuberculosis phagosome maturation also sheds light on fundamental aspects of phagolysosome biogenesis. The maturation block involves interference with the recruitment and function of rabs, rab effectors (phosphatidylinositol 3-kinases and tethering molecules such as EEA1), SNAREs (Syntaxin 6 and cellubrevin) and Ca2+/calmodulin signaling. M. tuberculosis analogs of mammalian phosphatidylinositols interfere with these systems and associated processes.
Authors:
Isabelle Vergne; Jennifer Chua; Vojo Deretic
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Traffic (Copenhagen, Denmark)     Volume:  4     ISSN:  1398-9219     ISO Abbreviation:  Traffic     Publication Date:  2003 Sep 
Date Detail:
Created Date:  2003-08-12     Completed Date:  2004-05-24     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  100939340     Medline TA:  Traffic     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  600-6     Citation Subset:  IM    
Affiliation:
Department of Molecular Genetics and Microbiology, University of New Mexico Medical School, Albuquerque, NM 87131, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers / chemistry
Biological Transport
Calcium / physiology
Calmodulin / physiology
Cell Membrane / metabolism
Humans
Mycobacterium tuberculosis / metabolism,  pathogenicity*,  physiology
Phagosomes / metabolism,  microbiology*
Phosphatidylinositol Phosphates / physiology*
Grant Support
ID/Acronym/Agency:
AI 42999/AI/NIAID NIH HHS; AI 45148/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Calmodulin; 0/Phosphatidylinositol Phosphates; 0/phosphatidylinositol 3-phosphate; 7440-70-2/Calcium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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