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Mycobacterium smegmatis genomic characteristics associated with its saprophyte lifestyle.
MedLine Citation:
PMID:  22628184     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Tuberculosis remains a great threat to global public health. The high biosafety level III required to tackle its causative agent Mycobacterium tuberculosis seriously hinders the exploration of its biology and new countermeasures. M. smegmatis is a widely recognized good surrogate of M.tuberculosis, largely due to their conserved transcriptional machinery, sigma factors and two-component systems. However, their distinct lifestyles often confound the explanation of the results. M.tuberculosis leads both parasitic and free life, while M.smegmatis is largely saprophyte. To make full advantage of this model, it is helpful to discover the genome features associated with M. smegmatis unique niches, such as its saprophytic life, high salt tolerance and relative short generation time. We employed the gene ontology enrichment analysis to characterize the unique lifestyle of M. smegmatis. Gene ontology enrichment analysis provided 24 terms, most are relevant to the special lifestyle of M. smegmatis, especially the saprophytic niche, high salt tolerance adaptation and short generation time. In-depth functional characterization of these genes will shed new lights on the genetic basis of M.smegmatis saprophytic life and hasten the understanding of the unique biology of M.tuberculosis. J. Cell. Biochem. © 2012 Wiley Periodicals, Inc.
Authors:
Quanxin Long; Qi Zhou; Lei Ji; Jun Wu; Wen Wang; Jianping Xie
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-5-24
Journal Detail:
Title:  Journal of cellular biochemistry     Volume:  -     ISSN:  1097-4644     ISO Abbreviation:  -     Publication Date:  2012 May 
Date Detail:
Created Date:  2012-5-25     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8205768     Medline TA:  J Cell Biochem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Wiley Periodicals, Inc.
Affiliation:
Institute of Modern Biopharmaceuticals, State Key Laboratory Breeding Base of Eco-Environment and Bio-Resource of the Three Gorges Area, School of Life Sciences, Southwest University, Chongqing 400715, China.
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