Document Detail

Mycobacterium hemophilum infection presenting as filamentary keratopathy in an immunocompromised adult.
MedLine Citation:
PMID:  17592336     Owner:  NLM     Status:  MEDLINE    
PURPOSE: To report a case of Mycobacterium hemophilum of the eye. METHODS: Case report with pathologic correlation. A 55-year-old Malaysian man with a 3-year history of graft-versus-host disease presented with dry eye and keratopathy. RESULTS: The diagnosis was not initially evident, despite biopsy specimens of the conjunctiva. Definitive diagnosis was made after dermatology consultation suggested a histoid variant of lepromatous leprosy, prompting Ziehl-Neelsen staining of the initial and subsequent conjunctival biopsies with subsequent polymerase chain reaction testing. Anti-M. hemophilum treatment resulted in prompt resolution of ocular signs. CONCLUSIONS: Mycobacterium hemophilum is a rare condition, affecting mainly immunocompromised patients. Although filamentary keratopathy has been described as common manifestations of leprosy, to date, no ocular manifestations of M. hemophilum have been described. Conjoint management with infectious disease and clinical microbiology is imperative to ensure accurate diagnosis and appropriate early intervention. The effect of systemic immunosuppression is relevant in such patients.
Michael James Millar; Carl Bulliard; Chandra Balachandran; Anthony J Maloof
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Cornea     Volume:  26     ISSN:  0277-3740     ISO Abbreviation:  Cornea     Publication Date:  2007 Jul 
Date Detail:
Created Date:  2007-06-26     Completed Date:  2007-10-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8216186     Medline TA:  Cornea     Country:  United States    
Other Details:
Languages:  eng     Pagination:  764-6     Citation Subset:  IM    
Department of Ophthalmology, Westmead Hospital, New South Wales, Australia.
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MeSH Terms
Conjunctival Diseases / diagnosis,  drug therapy,  microbiology*
Corneal Diseases / diagnosis,  drug therapy,  microbiology*
Eye Infections, Bacterial / diagnosis,  drug therapy,  microbiology*
Graft vs Host Disease / drug therapy,  immunology
Immunocompromised Host*
Immunosuppressive Agents / therapeutic use
Middle Aged
Mycobacterium Infections / diagnosis,  drug therapy,  microbiology*
Mycobacterium haemophilum / isolation & purification*
Reg. No./Substance:
0/Immunosuppressive Agents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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