| Mycobacterium chelonae-abscessus complex associated with sinopulmonary disease, Northeastern USA. | |
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MedLine Citation:
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PMID: 21888796 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Members of the Mycobacterium chelonae-abscessus complex represent Mycobacterium species that cause invasive infections in immunocompetent and immunocompromised hosts. We report the detection of a new pathogen that had been misidentified as M. chelonae with an atypical antimicrobial drug susceptibility profile. The discovery prompted a multicenter investigation of 26 patients. Almost all patients were from the northeastern United States, and most had underlying sinus or pulmonary disease. Infected patients had clinical features similar to those with M. abscessus infections. Taxonomically, the new pathogen shared molecular identity with members of the M. chelonae-abscessus complex. Multilocus DNA target sequencing, DNA-DNA hybridization, and deep multilocus sequencing (43 full-length genes) support a new taxon for these microorganisms. Because most isolates originated in Pennsylvania, we propose the name M. franklinii sp. nov. This investigation underscores the need for accurate identification of Mycobacterium spp. to detect new pathogens implicated in human disease. |
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Authors:
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Keith E Simmon; Barbara A Brown-Elliott; Perry G Ridge; Jacob D Durtschi; Linda Bridge Mann; E Susan Slechta; Arnold G Steigerwalt; Benjamin D Moser; Anne M Whitney; June M Brown; Karl V Voelkerding; Karin L McGowan; Anne F Reilly; Thomas J Kirn; W Ray Butler; Paul H Edelstein; Richard J Wallace; Cathy A Petti |
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Publication Detail:
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Type: Journal Article; Multicenter Study |
Journal Detail:
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Title: Emerging infectious diseases Volume: 17 ISSN: 1080-6059 ISO Abbreviation: Emerging Infect. Dis. Publication Date: 2011 Sep |
Date Detail:
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Created Date: 2011-09-05 Completed Date: 2012-02-23 Revised Date: 2012-04-30 |
Medline Journal Info:
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Nlm Unique ID: 9508155 Medline TA: Emerg Infect Dis Country: United States |
Other Details:
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Languages: eng Pagination: 1692-700 Citation Subset: IM |
Affiliation:
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Associated Regional and University Pathologists Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA. ke.monk@gmail.com |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Anti-Bacterial Agents / pharmacology Bacterial Proteins / genetics Chaperonin 60 / genetics DNA, Ribosomal Spacer / genetics Female High-Throughput Nucleotide Sequencing Humans Male Microbial Sensitivity Tests Middle Aged Multilocus Sequence Typing Mycobacterium Infections, Nontuberculous / diagnosis, microbiology* Mycobacterium chelonae / classification, drug effects, isolation & purification Nontuberculous Mycobacteria / classification, drug effects, isolation & purification* Pennsylvania Phylogeny RNA, Ribosomal, 16S / genetics Respiratory Tract Infections / diagnosis, microbiology* Sinusitis / diagnosis, microbiology* Superoxide Dismutase / genetics |
| Chemical | |
Reg. No./Substance:
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0/Anti-Bacterial Agents; 0/Bacterial Proteins; 0/Chaperonin 60; 0/DNA, Ribosomal Spacer; 0/RNA, Ribosomal, 16S; 0/SodA protein, Bacteria; 0/heat-shock protein 65, Mycobacterium; EC 1.15.1.1/Superoxide Dismutase |
| Full Text | |
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Journal Information Journal ID (nlm-ta): Emerg Infect Dis Journal ID (iso-abbrev): Emerging Infect. Dis Journal ID (publisher-id): EID ISSN: 1080-6040 ISSN: 1080-6059 Publisher: Centers for Disease Control and Prevention |
Article Information Print publication date: Month: 9 Year: 2011 Volume: 17 Issue: 9 First Page: 1692 Last Page: 1700 ID: 3322061 PubMed Id: 21888796 Publisher Id: 10-1667 DOI: 10.3201/eid1709.101667 |
| Mycobacterium chelonae-abscessus Complex Associated with Sinopulmonary Disease, Northeastern USA Alternate Title:M. chelonae-abscessus Complex, USA | |
| Keith E. Simmon | |
| Barbara A. Brown-Elliott | |
| Perry G. Ridge | |
| Jacob D. Durtschi | |
| Linda Bridge Mann | |
| E. Susan Slechta | |
| Arnold G. Steigerwalt | |
| Benjamin D. Moser | |
| Anne M. Whitney | |
| June M. Brown | |
| Karl V. Voelkerding | |
| Karin L. McGowan | |
| Anne F. Reilly | |
| Thomas J. Kirn | |
| W. Ray Butler | |
| Paul H. Edelstein | |
| Richard J. Wallace, Jr. | |
| Cathy A. Petti | |
| Author affiliations: Associated Regional and University Pathologists Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, USA (K.E. Simmon, P.G. Ridge, J.D. Durtschi, E.S. Slechta, K.V. Voelkerding, C.A. Petti); |
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| University of Texas Health Science Center, Tyler, Texas, USA (B.A. Brown-Elliott, L.B. Mann, R.J. Wallace, Jr.); |
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| Centers for Disease Control and Prevention, Atlanta, Georgia, USA (A.G. Steigerwalt, B.D. Moser, A.M. Whitney, J.M. Brown, W.R. Butler); |
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| University of Utah School of Medicine, Salt Lake City, Utah, USA (K.V. Voelkerding, C.A. Petti); |
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| University of Pennsylvania School of Medicine at Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA (K.F. McGowan, A.F. Reilly); |
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| Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA (T.J. Kirn); |
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| University of Pennsylvania Medical Center, Philadelphia (P.H. Edelstein) |
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Medscape, LLC is pleased to provide online continuing medical education (CME) for this journal article, allowing clinicians the opportunity to earn CME credit.
This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Medscape, LLC and Emerging Infectious Diseases. Medscape, LLC is accredited by the ACCME to provide continuing medical education for physicians.
Medscape, LLC designates this Journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.
All other clinicians completing this activity will be issued a certificate of participation. To participate in this journal CME activity: (1) review the learning objectives and author disclosures; (2) study the education content; (3) take the post-test with a 70% minimum passing score and complete the evaluation at www.medscape.org/journal/eid; (4) view/print certificate.
Release date: August 22, 2011; Expiration date: August 22, 2012
Upon completion of this activity, participants will be able to:
- Analyze the M. chelonae-abscessus complex
- Distinguish the molecular identity of “M. franklinii”
- Identify the most common clinical source of “M. franklinii”
- Evaluate the antimicrobial susceptibility of “M. franklinii”
Beverly Merritt, Technical Writer/Editor, Emerging Infectious Diseases. Disclosure: Beverly Merritt has disclosed no relevant financial relationships.
Charles P. Vega, MD, Associate Professor; Residency Director, Department of Family Medicine, University of California, Irvine. Disclosure: Charles P. Vega, MD, has disclosed no relevant financial relationships.
Disclosures: Barbara A. Brown-Elliott, MS; Perry G. Ridge; Jacob D. Durtschi, BS; Linda Bridge Mann, BS; E. Susan Slechta; Arnold G. Steigerwalt, BS; Benjamin D. Moser; Anne M. Whitney, PhD; June M. Brown, BS; Karl V. Voelkerding, MD; Karin L. McGowan, PhD; Anne F. Reilly, MD, MPH; W. Ray Butler, MS; Paul H. Edelstein, MD; and Richard J. Wallace Jr., MD, have disclosed no relevant financial relationships. Keith E. Simmon, BS, has disclosed the following relevant financial relationships: employed by: Isentio US/Software company (non-FDA). Thomas J. Kirn, MD, has disclosed the following relevant financial relationships: served as an advisor or consultant for Merck Sharpe and Dohme. Cathy A. Petti, MD, has disclosed the following relevant financial relationships: was an employee for Novartis Diagnostics from 2009–2010.
Article Categories:
Keywords: Keywords: bacteria, rapid-growing mycobacteria, multilocus sequencing, Mycobacterium chelonae-abscessus complex, Mycobacterium franklinii, sinopulmonary disease, tuberculosis and other mycobacteria, United States, CME, research. Keywords: Suggested citation for this article: Simmon KE, Brown-Elliott BA, Ridge PG, Durtschi JD, Mann LB, Slechta ES, et al. Mycobacterium chelonae-abscessus complex associated with sinopulmonary disease, northeastern USA. Emerg Infect Dis [serial on the Internet]. 2011 Sep [date cited]. http://dx.doi.org/10.3201/eid1709.101667. |
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