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Mycobacterium chelonae-abscessus complex associated with sinopulmonary disease, Northeastern USA.
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MedLine Citation:
PMID:  21888796     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Members of the Mycobacterium chelonae-abscessus complex represent Mycobacterium species that cause invasive infections in immunocompetent and immunocompromised hosts. We report the detection of a new pathogen that had been misidentified as M. chelonae with an atypical antimicrobial drug susceptibility profile. The discovery prompted a multicenter investigation of 26 patients. Almost all patients were from the northeastern United States, and most had underlying sinus or pulmonary disease. Infected patients had clinical features similar to those with M. abscessus infections. Taxonomically, the new pathogen shared molecular identity with members of the M. chelonae-abscessus complex. Multilocus DNA target sequencing, DNA-DNA hybridization, and deep multilocus sequencing (43 full-length genes) support a new taxon for these microorganisms. Because most isolates originated in Pennsylvania, we propose the name M. franklinii sp. nov. This investigation underscores the need for accurate identification of Mycobacterium spp. to detect new pathogens implicated in human disease.
Authors:
Keith E Simmon; Barbara A Brown-Elliott; Perry G Ridge; Jacob D Durtschi; Linda Bridge Mann; E Susan Slechta; Arnold G Steigerwalt; Benjamin D Moser; Anne M Whitney; June M Brown; Karl V Voelkerding; Karin L McGowan; Anne F Reilly; Thomas J Kirn; W Ray Butler; Paul H Edelstein; Richard J Wallace; Cathy A Petti
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Publication Detail:
Type:  Journal Article; Multicenter Study    
Journal Detail:
Title:  Emerging infectious diseases     Volume:  17     ISSN:  1080-6059     ISO Abbreviation:  Emerging Infect. Dis.     Publication Date:  2011 Sep 
Date Detail:
Created Date:  2011-09-05     Completed Date:  2012-02-23     Revised Date:  2013-06-27    
Medline Journal Info:
Nlm Unique ID:  9508155     Medline TA:  Emerg Infect Dis     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1692-700     Citation Subset:  IM    
Affiliation:
Associated Regional and University Pathologists Institute for Clinical and Experimental Pathology, Salt Lake City, UT 84108, USA. ke.monk@gmail.com
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Anti-Bacterial Agents / pharmacology
Bacterial Proteins / genetics
Chaperonin 60 / genetics
DNA, Ribosomal Spacer / genetics
Female
High-Throughput Nucleotide Sequencing
Humans
Male
Microbial Sensitivity Tests
Middle Aged
Multilocus Sequence Typing
Mycobacterium Infections, Nontuberculous / diagnosis,  microbiology*
Mycobacterium chelonae / classification,  drug effects,  isolation & purification
Nontuberculous Mycobacteria / classification,  drug effects,  isolation & purification*
Pennsylvania
Phylogeny
RNA, Ribosomal, 16S / genetics
Respiratory Tract Infections / diagnosis,  microbiology*
Sinusitis / diagnosis,  microbiology*
Superoxide Dismutase / genetics
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Bacterial Proteins; 0/Chaperonin 60; 0/DNA, Ribosomal Spacer; 0/RNA, Ribosomal, 16S; 0/SodA protein, Bacteria; 0/heat-shock protein 65, Mycobacterium; EC 1.15.1.1/Superoxide Dismutase
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Full Text
Journal Information
Journal ID (nlm-ta): Emerg Infect Dis
Journal ID (iso-abbrev): Emerging Infect. Dis
Journal ID (publisher-id): EID
ISSN: 1080-6040
ISSN: 1080-6059
Publisher: Centers for Disease Control and Prevention
Article Information

Print publication date: Month: 9 Year: 2011
Volume: 17 Issue: 9
First Page: 1692 Last Page: 1700
ID: 3322061
PubMed Id: 21888796
Publisher Id: 10-1667
DOI: 10.3201/eid1709.101667

Mycobacterium chelonae-abscessus Complex Associated with Sinopulmonary Disease, Northeastern USA Alternate Title:M. chelonae-abscessus Complex, USA
Keith E. Simmon
Barbara A. Brown-Elliott
Perry G. Ridge
Jacob D. Durtschi
Linda Bridge Mann
E. Susan Slechta
Arnold G. Steigerwalt
Benjamin D. Moser
Anne M. Whitney
June M. Brown
Karl V. Voelkerding
Karin L. McGowan
Anne F. Reilly
Thomas J. Kirn
W. Ray Butler
Paul H. Edelstein
Richard J. Wallace, Jr.
Cathy A. Petti
Author affiliations: Associated Regional and University Pathologists Institute for Clinical and Experimental Pathology, Salt Lake City, Utah, USA (K.E. Simmon, P.G. Ridge, J.D. Durtschi, E.S. Slechta, K.V. Voelkerding, C.A. Petti);
University of Texas Health Science Center, Tyler, Texas, USA (B.A. Brown-Elliott, L.B. Mann, R.J. Wallace, Jr.);
Centers for Disease Control and Prevention, Atlanta, Georgia, USA (A.G. Steigerwalt, B.D. Moser, A.M. Whitney, J.M. Brown, W.R. Butler);
University of Utah School of Medicine, Salt Lake City, Utah, USA (K.V. Voelkerding, C.A. Petti);
University of Pennsylvania School of Medicine at Children’s Hospital of Philadelphia, Philadelphia, Pennsylvania, USA (K.F. McGowan, A.F. Reilly);
Robert Wood Johnson Medical School, New Brunswick, New Jersey, USA (T.J. Kirn);
University of Pennsylvania Medical Center, Philadelphia (P.H. Edelstein)

MEDSCAPE CME

Medscape, LLC is pleased to provide online continuing medical education (CME) for this journal article, allowing clinicians the opportunity to earn CME credit.

This activity has been planned and implemented in accordance with the Essential Areas and policies of the Accreditation Council for Continuing Medical Education through the joint sponsorship of Medscape, LLC and Emerging Infectious Diseases. Medscape, LLC is accredited by the ACCME to provide continuing medical education for physicians.

Medscape, LLC designates this Journal-based CME activity for a maximum of 1 AMA PRA Category 1 Credit(s)TM. Physicians should claim only the credit commensurate with the extent of their participation in the activity.

All other clinicians completing this activity will be issued a certificate of participation. To participate in this journal CME activity: (1) review the learning objectives and author disclosures; (2) study the education content; (3) take the post-test with a 70% minimum passing score and complete the evaluation at www.medscape.org/journal/eid; (4) view/print certificate.

Release date: August 22, 2011; Expiration date: August 22, 2012


Learning Objectives

Upon completion of this activity, participants will be able to:

  • Analyze the M. chelonae-abscessus complex
  • Distinguish the molecular identity of “M. franklinii
  • Identify the most common clinical source of “M. franklinii
  • Evaluate the antimicrobial susceptibility of “M. franklinii

MEDSCAPE CME EDITOR

Beverly Merritt, Technical Writer/Editor, Emerging Infectious Diseases. Disclosure: Beverly Merritt has disclosed no relevant financial relationships.


MEDSCAPE CME AUTHOR

Charles P. Vega, MD, Associate Professor; Residency Director, Department of Family Medicine, University of California, Irvine. Disclosure: Charles P. Vega, MD, has disclosed no relevant financial relationships.


AUTHORS

Disclosures: Barbara A. Brown-Elliott, MS; Perry G. Ridge; Jacob D. Durtschi, BS; Linda Bridge Mann, BS; E. Susan Slechta; Arnold G. Steigerwalt, BS; Benjamin D. Moser; Anne M. Whitney, PhD; June M. Brown, BS; Karl V. Voelkerding, MD; Karin L. McGowan, PhD; Anne F. Reilly, MD, MPH; W. Ray Butler, MS; Paul H. Edelstein, MD; and Richard J. Wallace Jr., MD, have disclosed no relevant financial relationships. Keith E. Simmon, BS, has disclosed the following relevant financial relationships: employed by: Isentio US/Software company (non-FDA). Thomas J. Kirn, MD, has disclosed the following relevant financial relationships: served as an advisor or consultant for Merck Sharpe and Dohme. Cathy A. Petti, MD, has disclosed the following relevant financial relationships: was an employee for Novartis Diagnostics from 2009–2010.



Article Categories:
  • CME
Article Categories:
  • Research
Article Categories:
  • Research

Keywords: Keywords: bacteria, rapid-growing mycobacteria, multilocus sequencing, Mycobacterium chelonae-abscessus complex, Mycobacterium franklinii, sinopulmonary disease, tuberculosis and other mycobacteria, United States, CME, research.
Keywords: Suggested citation for this article: Simmon KE, Brown-Elliott BA, Ridge PG, Durtschi JD, Mann LB, Slechta ES, et al. Mycobacterium chelonae-abscessus complex associated with sinopulmonary disease, northeastern USA. Emerg Infect Dis [serial on the Internet]. 2011 Sep [date cited]. http://dx.doi.org/10.3201/eid1709.101667.

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