| Mycobacterium bovis BCG-induced human T-cell clones from BCG-vaccinated healthy subjects: antigen specificity and lymphokine production. | |
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MedLine Citation:
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PMID: 2427449 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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A total of 121 human T-cell clones were raised from nine Mycobacterium bovis BCG-vaccinated healthy individuals. Three clones were autoreactive, 74 responded to BCG in the presence of antigen-presenting cells, and the others required in addition exogenous interleukin 2. Only one clone was CD8+ CD4-, and the rest were CD4+ CD8-. Testing with a panel of mycobacteria suggested that the clones were recognizing epitopes of varied specificity. Out of 44 clones tested, 15 were specific to BCG and Mycobacterium tuberculosis, 22 showed limited cross-reactivity, and 8 were broadly cross-reactive. None of the 22 BCG responder clones could differentiate between Danish, French, Prague, and Moreau strains of BCG. BCG and M. tuberculosis H37Rv also paralleled very closely; however, 6 of 18 BCG- and M. tuberculosis H37Rv-responding clones did not proliferate to Mycobacterium africanum. BCG- and M. tuberculosis H37Rv-specific as well as cross-reactive T-cell clones could be induced to produce interleukin 2, gamma interferon, and granulocyte-macrophage colony-stimulating factor activity. |
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Authors:
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A S Mustafa; G Kvalheim; M Degre; T Godal |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Infection and immunity Volume: 53 ISSN: 0019-9567 ISO Abbreviation: Infect. Immun. Publication Date: 1986 Sep |
Date Detail:
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Created Date: 1986-10-15 Completed Date: 1986-10-15 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 491-7 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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BCG Vaccine
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immunology* Cross Reactions Epitopes / analysis* Humans Interleukin-2 / biosynthesis Lymphokines / biosynthesis* Mycobacterium tuberculosis / immunology Phenotype T-Lymphocytes / immunology* Vaccination |
| Chemical | |
Reg. No./Substance:
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0/BCG Vaccine; 0/Epitopes; 0/Interleukin-2; 0/Lymphokines |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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