Document Detail


Mycobacterium bovis BCG-induced human T-cell clones from BCG-vaccinated healthy subjects: antigen specificity and lymphokine production.
MedLine Citation:
PMID:  2427449     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A total of 121 human T-cell clones were raised from nine Mycobacterium bovis BCG-vaccinated healthy individuals. Three clones were autoreactive, 74 responded to BCG in the presence of antigen-presenting cells, and the others required in addition exogenous interleukin 2. Only one clone was CD8+ CD4-, and the rest were CD4+ CD8-. Testing with a panel of mycobacteria suggested that the clones were recognizing epitopes of varied specificity. Out of 44 clones tested, 15 were specific to BCG and Mycobacterium tuberculosis, 22 showed limited cross-reactivity, and 8 were broadly cross-reactive. None of the 22 BCG responder clones could differentiate between Danish, French, Prague, and Moreau strains of BCG. BCG and M. tuberculosis H37Rv also paralleled very closely; however, 6 of 18 BCG- and M. tuberculosis H37Rv-responding clones did not proliferate to Mycobacterium africanum. BCG- and M. tuberculosis H37Rv-specific as well as cross-reactive T-cell clones could be induced to produce interleukin 2, gamma interferon, and granulocyte-macrophage colony-stimulating factor activity.
Authors:
A S Mustafa; G Kvalheim; M Degre; T Godal
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Infection and immunity     Volume:  53     ISSN:  0019-9567     ISO Abbreviation:  Infect. Immun.     Publication Date:  1986 Sep 
Date Detail:
Created Date:  1986-10-15     Completed Date:  1986-10-15     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0246127     Medline TA:  Infect Immun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  491-7     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
BCG Vaccine / immunology*
Cross Reactions
Epitopes / analysis*
Humans
Interleukin-2 / biosynthesis
Lymphokines / biosynthesis*
Mycobacterium tuberculosis / immunology
Phenotype
T-Lymphocytes / immunology*
Vaccination
Chemical
Reg. No./Substance:
0/BCG Vaccine; 0/Epitopes; 0/Interleukin-2; 0/Lymphokines
Comments/Corrections

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