Document Detail


Mycobacterium abscessus infection in solid organ transplant recipients: report of three cases and review of the literature.
MedLine Citation:
PMID:  19671119     Owner:  NLM     Status:  In-Process    
Abstract/OtherAbstract:
Mycobacterium abscessus is an ubiquitous organism found in the environment. This rapidly growing mycobacterium infrequently causes disease in humans; however, in immunocompromised hosts, disease can range from localized cutaneous lesions to disseminated infection. The organism is resistant to most antimycobacterial drugs and therapy can be limited by drug interactions. The exact incidence of M. abscessus infection among solid organ transplant (SOT) recipients is unknown; data are only available from previously reported cases in the literature. We describe 3 cases of M. abscessus infection in SOT recipients diagnosed within a 5-month period. One of the cases followed multi-visceral transplantation, the first such case to be reported in the literature. An epidemiological investigation did not reveal significant commonalities among the cases, and pulsed-field gel electrophoresis of genomic DNA of the case isolates confirmed their non-identity. All cases improved with antibiotic therapy, most notably with the new glycylcycline, tigecycline, along with surgical intervention in 2 of the cases. In addition, we review features and characteristics of M. abscessus infections in recipients of SOT reported in the literature from 1992 to 2008 and summarize some selected therapeutic concerns and issues related to treatment.
Authors:
A P Garrison; M I Morris; S Doblecki Lewis; L Smith; T J Cleary; G W Procop; V Vincek; I Rosa-Cunha; B Alfonso; G W Burke; A Tzakis; A I Hartstein
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Publication Detail:
Type:  Journal Article     Date:  2009-08-10
Journal Detail:
Title:  Transplant infectious disease : an official journal of the Transplantation Society     Volume:  11     ISSN:  1399-3062     ISO Abbreviation:  Transpl Infect Dis     Publication Date:  2009 Dec 
Date Detail:
Created Date:  2009-12-03     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  100883688     Medline TA:  Transpl Infect Dis     Country:  Denmark    
Other Details:
Languages:  eng     Pagination:  541-8     Citation Subset:  IM    
Affiliation:
University of Miami Miller School of Medicine, Florida, 33136, USA.
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