Document Detail


Mycobacteriocidal action of exogenous nitric oxide.
MedLine Citation:
PMID:  9925545     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We tested the hypothesis that exposure of extracellular Mycobacterium tuberculosis to low concentrations (< 100 ppm) of nitric oxide (NO) for short periods (24 h or less) will result in microbial killing. We observed that NO had both dose- and time-dependent cidal effects that were very significant by two-way analysis of variance (F ratios of 13.4 [P < 0.001] and 98.1 [P < 0.0001], respectively). Conceivably, extracellular bacilli in patients with pulmonary tuberculosis might be vulnerable to exogenous NO.
Authors:
R Long; B Light; J A Talbot
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Antimicrobial agents and chemotherapy     Volume:  43     ISSN:  0066-4804     ISO Abbreviation:  Antimicrob. Agents Chemother.     Publication Date:  1999 Feb 
Date Detail:
Created Date:  1999-04-21     Completed Date:  1999-04-21     Revised Date:  2013-06-11    
Medline Journal Info:
Nlm Unique ID:  0315061     Medline TA:  Antimicrob Agents Chemother     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  403-5     Citation Subset:  IM    
Affiliation:
Department of Medicine, University of Alberta, Edmonton, Canada. richardlong@health.gov.ab.ca
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MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / pharmacology*,  therapeutic use
Dose-Response Relationship, Drug
Humans
Microbial Sensitivity Tests
Mycobacterium tuberculosis / drug effects*
Nitric Oxide / pharmacology*,  therapeutic use
Tuberculosis, Pulmonary / drug therapy,  microbiology
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 10102-43-9/Nitric Oxide
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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