| Mycobacteria-infected bystander macrophages trigger maturation of dendritic cells and enhance their ability to mediate HIV transinfection. | |
| | |
MedLine Citation:
|
PMID: 22539293 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
|
Synergistic interplay between Mycobacterium tuberculosis (Mtb) and HIV in coinfected ind-ividuals leads to the acceleration of both tuberculosis and HIVdisease. Mtb, as well as HIV, may modulate the function of many immune cells, including DCs. To dissect the bystander impact of Mφs infected with Mtb on DC functionality, we here investigated changes in DC phenotype, cytokine profiles, and HIV-1 transinfecting ability. An in vitro system was used in which human monocyte-derived DCs were exposed to soluble factors released by Mφs infected with mycobacteria, including virulent clinical Mtb isolates and nonvirulent BCG. Soluble factors secreted from Mtb-infected Mφs, and to a lesser extent BCG-infected Mφs, resulted in the production of proinflammatory cytokines and partial upregulation of DC maturation markers. Interestingly, the HIV-1 transinfecting ability of DCs was enhanced upon exposure to soluble factors released by Mtb-infected Mφs. In summary, our study shows that DCs exposed to soluble factors released by mycobacteria-infected Mφs undergo maturation and display an augmented ability to transmit HIV-1 in trans. These findings highlight the important role of bystander effects during the course of Mtb-HIV coinfection and suggest that Mtb-infected Mφs may contribute to an environment that supports DC-mediated spread and amplification of HIV in coinfected individuals. |
| | |
Authors:
|
Jolanta Mazurek; Lech Ignatowicz; Gunilla Källenius; Marianne Jansson; Andrzej Pawlowski |
Related Documents
:
|
22677253 - Treatment for hepatitis b virus (hbv) and hepatitis c virus (hcv) infection - danish na... 8158053 - Polymerase chain reaction-based diagnosis of onchocerca volvulus infection: improved de... 10068093 - Immunodominant b-cell domains of hepatitis c virus envelope proteins e1 and e2 identifi... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: European journal of immunology Volume: 42 ISSN: 1521-4141 ISO Abbreviation: Eur. J. Immunol. Publication Date: 2012 May |
Date Detail:
|
Created Date: 2012-04-27 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 1273201 Medline TA: Eur J Immunol Country: Germany |
Other Details:
|
Languages: eng Pagination: 1192-202 Citation Subset: IM |
Copyright Information:
|
© 2012 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim. |
Affiliation:
|
Department of Microbiology, Tumor and Cell Biology, Karolinska Institutet, Stockholm, Sweden; Swedish Institute for Infectious Disease Control, Solna, Sweden. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Blockade of Tim-3 signaling restores the virus-specific CD8(+) T-cell response in patients with chr...
Next Document: Double negative Treg cells promote nonmyeloablative bone marrow chimerism by inducing T-cell clonal ...