Document Detail

"Mycelial vaginal test" and Candida susceptibility.
MedLine Citation:
PMID:  2698795     Owner:  NLM     Status:  MEDLINE    
We have investigated the possibility of vaginal liquids affecting the transition from a yeast form (Y) to a mycelial one (M) in C. albicans and the possible relation to microbial flora, pH and glycogen. The C. albicans Y----M conversion, "mycelial vaginal test", in 250 specimens of vaginal liquid shows a 70% positivity rate against a test Candida strain. Results of the vaginal test are not related to bacteria, flora and pH, but to Candida infection and to glycogen concentration. Using a Y----M good-responder Candida strain in the vaginal test it is possible to have a global index of the factors affecting the Candida filamentation in the host. It can be advisable to utilize the vaginal test as a virulence test for Candida strains and as an indicative test of phenotypic drug resistance.
G Simonetti; N Simonetti; A Villa
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Drugs under experimental and clinical research     Volume:  15     ISSN:  0378-6501     ISO Abbreviation:  Drugs Exp Clin Res     Publication Date:  1989  
Date Detail:
Created Date:  1990-05-16     Completed Date:  1990-05-16     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7802135     Medline TA:  Drugs Exp Clin Res     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  487-90     Citation Subset:  IM    
Institute of Microbiology-Pharmacology, University of Rome, La Sapienza, Italy.
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MeSH Terms
Candida albicans / drug effects*,  growth & development
Candidiasis, Vulvovaginal / microbiology
Glycogen / metabolism
Vagina / microbiology*
Reg. No./Substance:

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