Document Detail

Myc, cell competition, and compensatory proliferation.
MedLine Citation:
PMID:  16061622     Owner:  NLM     Status:  MEDLINE    
The proto-oncogene Myc is already known to affect many cellular processes, but recent experiments in the fruit fly Drosophila melanogaster have revealed yet a new facet of Myc. Neighboring cells were shown to compare their Myc levels and the losers (cells with lower Myc activity) were actively eliminated. This phenomenon is called "cell competition," and it seems to be part of a developmental size and quality control program. Subversion of this mechanism may contribute to the transforming powers of Myc and possibly other oncogenes.
Peter Gallant
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Cancer research     Volume:  65     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  2005 Aug 
Date Detail:
Created Date:  2005-08-02     Completed Date:  2005-10-04     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  United States    
Other Details:
Languages:  eng     Pagination:  6485-7     Citation Subset:  IM    
Zoologisches Institut, Universitaet Zurich, Zurich, Switzerland.
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MeSH Terms
Cell Communication / physiology*
Cell Growth Processes / physiology
Proto-Oncogene Proteins c-myc / physiology*
Reg. No./Substance:
0/Proto-Oncogene Proteins c-myc

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