Document Detail

Myasthenic crisis. Response to plasmapheresis following failure of intravenous gamma-globulin.
MedLine Citation:
PMID:  8352670     Owner:  NLM     Status:  MEDLINE    
Myasthenic crisis is a potentially life-threatening complication of myasthenia gravis that requires aggressive therapy. We describe four patients in whom myasthenic crisis developed and who failed to respond to initial treatment with intravenous gamma-globulin. All four patients subsequently responded to intensive plasma exchange. Based on our experience, plasmapheresis appears to be superior to intravenous gamma-globulin for the treatment of myasthenic crisis in certain patients. Prognostic factors that determine the effectiveness of intravenous gamma-globulin vs plasmapheresis in these patients merit further investigation.
R B Stricker; B J Kwiatkowska; J A Habis; D D Kiprov
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Archives of neurology     Volume:  50     ISSN:  0003-9942     ISO Abbreviation:  Arch. Neurol.     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1993-09-15     Completed Date:  1993-09-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0372436     Medline TA:  Arch Neurol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  837-40     Citation Subset:  AIM; IM    
Department of Medicine, California Pacific Medical Center, San Francisco, 94120.
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MeSH Terms
Autoantibodies / blood
Immunoglobulins, Intravenous
Middle Aged
Myasthenia Gravis / immunology,  therapy*
Receptors, Cholinergic / immunology
Reg. No./Substance:
0/Autoantibodies; 0/Immunoglobulins, Intravenous; 0/Receptors, Cholinergic

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