Document Detail

Myasthenia gravis with thymoma is not associated with an increased incidence of non-muscle autoimmune disorders.
MedLine Citation:
PMID:  1571478     Owner:  NLM     Status:  MEDLINE    
Three groups of thymectomized patients with myasthenia gravis (MG) were selected for study, 16 with thymoma, 16 with thymic atrophy and 32 with follicular hyperplasia of the thymus. All 16 patients with thymoma, 15/16 with thymus atrophy and 30/32 with follicular hyperplasia had AChR antibodies. Non-receptor muscle (CA) antibodies were found in sera of 15/16 patients with thymoma, 3/16 with thymus atrophy and in none of the sera from patients with follicular hyperplasia. There were 2 patients with thymoma and polymyositis, but none of the thymoma patients had rheumatoid arthritis (RA), systemic lupus erythematosus (SLE) or other autoimmune disorders. Among the 32 patients with follicular hyperplasia of the thymus were 2 with SLE, 2 with RA and 1 with juvenile diabetes mellitus. In this study, there was an increased incidence of non-muscle autoimmune disorders among MG patients with follicular hyperplasia of the thymus but not among MG patients with thymoma.
J A Aarli; N E Gilhus; R Matre
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Autoimmunity     Volume:  11     ISSN:  0891-6934     ISO Abbreviation:  Autoimmunity     Publication Date:  1992  
Date Detail:
Created Date:  1992-06-01     Completed Date:  1992-06-01     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8900070     Medline TA:  Autoimmunity     Country:  SWITZERLAND    
Other Details:
Languages:  eng     Pagination:  159-62     Citation Subset:  IM    
Department of Neurology, Gade Institute, University Hospital, University of Bergen, Norway.
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MeSH Terms
Autoantibodies / analysis
Autoimmune Diseases / epidemiology,  etiology*
Middle Aged
Muscles / immunology
Myasthenia Gravis / etiology*
Receptors, Nicotinic / immunology
Thymoma / complications*,  surgery
Thymus Gland / pathology
Thymus Neoplasms / complications*,  surgery
Reg. No./Substance:
0/Autoantibodies; 0/Receptors, Nicotinic

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