Document Detail

Myasthenia gravis and steroid-induced myopathy of the respiratory muscles.
MedLine Citation:
PMID:  1469182     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: We report a case of corticosteroid-induced myopathy with involvement of respiratory muscles observed in a myasthenic patient. PATIENT: A 37-years-old woman, under corticosteroid treatment for two years for typical myasthenia gravis was admitted to ICU for acute myasthenic respiratory failure. Weaning from mechanical ventilation remained impossible despite 4 plasma exchanges and azathioprine. The patient exhibited a progressive 12 kg weight loss with muscular weakness and atrophy. MEASUREMENTS AND RESULTS: Peripheral and diaphragmatic electromyography as well as histological study were consistent with a steroid-induced myopathy. Discontinuation of corticosteroid treatment was followed by a rapid weight gain with general improvement and allowed weaning from mechanical ventilation with a complete recovery. CONCLUSION: This case provides evidence that corticosteroid-induced myopathy may be observed in myasthenia gravis and may involve the respiratory muscles as well as the peripheral musculature.
B Vallet; F Fourrier; J F Hurtevent; M Parent; C Chopin
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Intensive care medicine     Volume:  18     ISSN:  0342-4642     ISO Abbreviation:  Intensive Care Med     Publication Date:  1992  
Date Detail:
Created Date:  1993-01-27     Completed Date:  1993-01-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7704851     Medline TA:  Intensive Care Med     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  424-6     Citation Subset:  IM    
Service de Réanimation Polyvalente, Hôpital B, CHRU, Lille, France.
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MeSH Terms
Adrenal Cortex Hormones / adverse effects*
Azathioprine / therapeutic use
Lung Volume Measurements
Myasthenia Gravis / classification,  complications,  drug therapy*
Plasma Exchange
Respiration, Artificial
Respiratory Insufficiency / chemically induced*,  diagnosis,  therapy
Respiratory Muscles / drug effects*,  physiopathology
Reg. No./Substance:
0/Adrenal Cortex Hormones; 446-86-6/Azathioprine

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