Document Detail

Myasthenia gravis: population differences in disease expression and acetylcholine receptor antibody titers between Chinese and Caucasians.
MedLine Citation:
PMID:  3484357     Owner:  NLM     Status:  MEDLINE    
Clinical features and anti-acetylcholine receptor (AChR) titers were compared in Chinese (n = 258) and Caucasian (n = 258) myasthenia gravis populations. The former had more early onset and ocular cases, lacked the Caucasian late onset peak, and had fewer severe cases. The distribution of anti-AChR titers was broadly similar in the two populations, and their sera reacted equally well with AChR in both races. The significantly lower (chi 2 = 14.6; p less than 0.001) median anti-AChR titer in the Chinese population can be accounted for by the higher frequency of ocular cases and lower frequency of moderate or severely affected cases.
H C Chiu; A Vincent; J Newsom-Davis; K H Hsieh; T Hung
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurology     Volume:  37     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1987 Dec 
Date Detail:
Created Date:  1987-12-28     Completed Date:  1987-12-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1854-7     Citation Subset:  AIM; IM    
Department of Neurological Science, Royal Free Hospital School of Medicine, London, UK.
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MeSH Terms
Antibodies / analysis*
Asian Continental Ancestry Group
Child, Preschool
European Continental Ancestry Group
Infant, Newborn
Middle Aged
Muscles / immunology
Myasthenia Gravis / immunology*
Receptors, Cholinergic / immunology*
Reg. No./Substance:
0/Antibodies; 0/Receptors, Cholinergic
Erratum In:
Neurology 1988 Sep;38(9):1504

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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