Document Detail


Myasthenia gravis and pipecuronium--report of two cases.
MedLine Citation:
PMID:  1320731     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The use of pipecuronium in two patients with myasthenia gravis undergoing thymectomy is described. Neuromuscular function was monitored throughout using the train-of-four (TOF) mechanical twitch response. The cumulative dose-response to pipecuronium was determined in both patients during nitrous oxide-oxygen-narcotic anaesthesia. Both patients were sensitive to pipecuronium. The ED50 doses of pipecuronium were 11.6 and 11.1 micrograms.kg-1 and the ED95 doses were 35 and 33.3 micrograms.kg-1 in patients #1 and 2 respectively. Edrophonium 1 mg.kg-1 and neostigmine 0.06 mg.kg-1 were administered to patients #1 and 2 respectively for antagonism of residual neuromuscular blockade at 25 per cent spontaneous recovery of first twitch (T1) of the TOF stimulation. As with other non-depolarizing muscle relaxants pipecuronium in reduced dosage and with careful neuromuscular monitoring can be used to provide surgical relaxation safely in patients with controlled myasthenia gravis.
Authors:
M Naguib; A Sari-Kouzel; M Ashour; M Seraj; F Messahel
Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Middle East journal of anesthesiology     Volume:  11     ISSN:  0544-0440     ISO Abbreviation:  Middle East J Anesthesiol     Publication Date:  1992 Feb 
Date Detail:
Created Date:  1992-08-13     Completed Date:  1992-08-13     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8604187     Medline TA:  Middle East J Anesthesiol     Country:  LEBANON    
Other Details:
Languages:  eng     Pagination:  381-90     Citation Subset:  IM    
Affiliation:
Division of Anaesthesia, King Khalid University Hospital, Saudi Arabia.
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MeSH Terms
Descriptor/Qualifier:
Adult
Androstane-3,17-diol / administration & dosage,  analogs & derivatives*
Female
Humans
Male
Middle Aged
Myasthenia Gravis / surgery*
Neuromuscular Blocking Agents / administration & dosage*
Pipecuronium
Piperazines / administration & dosage*
Thymectomy*
Chemical
Reg. No./Substance:
0/Neuromuscular Blocking Agents; 0/Piperazines; 25126-76-5/Androstane-3,17-diol; 68399-58-6/Pipecuronium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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