| Myasthenia gravis and pipecuronium--report of two cases. | |
| | |
MedLine Citation:
|
PMID: 1320731 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
The use of pipecuronium in two patients with myasthenia gravis undergoing thymectomy is described. Neuromuscular function was monitored throughout using the train-of-four (TOF) mechanical twitch response. The cumulative dose-response to pipecuronium was determined in both patients during nitrous oxide-oxygen-narcotic anaesthesia. Both patients were sensitive to pipecuronium. The ED50 doses of pipecuronium were 11.6 and 11.1 micrograms.kg-1 and the ED95 doses were 35 and 33.3 micrograms.kg-1 in patients #1 and 2 respectively. Edrophonium 1 mg.kg-1 and neostigmine 0.06 mg.kg-1 were administered to patients #1 and 2 respectively for antagonism of residual neuromuscular blockade at 25 per cent spontaneous recovery of first twitch (T1) of the TOF stimulation. As with other non-depolarizing muscle relaxants pipecuronium in reduced dosage and with careful neuromuscular monitoring can be used to provide surgical relaxation safely in patients with controlled myasthenia gravis. |
| | |
Authors:
|
M Naguib; A Sari-Kouzel; M Ashour; M Seraj; F Messahel |
Publication Detail:
|
Type: Case Reports; Journal Article |
Journal Detail:
|
Title: Middle East journal of anesthesiology Volume: 11 ISSN: 0544-0440 ISO Abbreviation: Middle East J Anesthesiol Publication Date: 1992 Feb |
Date Detail:
|
Created Date: 1992-08-13 Completed Date: 1992-08-13 Revised Date: 2004-11-17 |
Medline Journal Info:
|
Nlm Unique ID: 8604187 Medline TA: Middle East J Anesthesiol Country: LEBANON |
Other Details:
|
Languages: eng Pagination: 381-90 Citation Subset: IM |
Affiliation:
|
Division of Anaesthesia, King Khalid University Hospital, Saudi Arabia. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Adult Androstane-3,17-diol / administration & dosage, analogs & derivatives* Female Humans Male Middle Aged Myasthenia Gravis / surgery* Neuromuscular Blocking Agents / administration & dosage* Pipecuronium Piperazines / administration & dosage* Thymectomy* |
| Chemical | |
Reg. No./Substance:
|
0/Neuromuscular Blocking Agents; 0/Piperazines; 25126-76-5/Androstane-3,17-diol; 68399-58-6/Pipecuronium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The cost of treating small cell lung cancer.
Next Document: Increased platelet sodium-proton exchange rates in insulin-dependent (type 1) diabetic patients with...