| Myasthenia gravis and invasive thymoma: a 20-year experience. | |
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MedLine Citation:
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PMID: 1237818 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In 20 years, 19 patients with myasthenia gravis and invasive thymoma have been seen by the Neurology Service at the UCLA Center for Health Sciences. This represents 4 percent of 493 myasthenia gravis patients seen during the same time and 37 percent of myasthenic patients with thymomas. Eight are still alive and 11 have died. Fifteen patients had the onset of myasthenic symptoms before discovery of the thymoma, while only four patients had chest symptoms and/or radiographic evidence of an anterior mediastinal mass prior to the onset of weakness. Radical excision of the tumor, if possible, and the remaining thymus, high dosage alternate day prednisone, and radiation therapy, if indicated, seem the treatments of choice. Recurrences of tumor nodules may necessitate further local radiation or the use of cytotoxic agents. |
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Authors:
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A J Goldman; C Herrmann; J C Keesey; D G Mulder; W J Brown |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Neurology Volume: 25 ISSN: 0028-3878 ISO Abbreviation: Neurology Publication Date: 1975 Nov |
Date Detail:
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Created Date: 1976-02-02 Completed Date: 1976-02-02 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1021-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Chlorambucil / therapeutic use Cyclophosphamide / therapeutic use Female Humans Male Middle Aged Myasthenia Gravis / complications* Neoplasm Recurrence, Local Neostigmine / therapeutic use Prednisone / therapeutic use Pyridostigmine Bromide / therapeutic use Thymectomy Thymoma / complications*, therapy Thymus Neoplasms / complications*, therapy |
| Chemical | |
Reg. No./Substance:
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101-26-8/Pyridostigmine Bromide; 305-03-3/Chlorambucil; 50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 59-99-4/Neostigmine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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