Document Detail


Myasthenia gravis and invasive thymoma: a 20-year experience.
MedLine Citation:
PMID:  1237818     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In 20 years, 19 patients with myasthenia gravis and invasive thymoma have been seen by the Neurology Service at the UCLA Center for Health Sciences. This represents 4 percent of 493 myasthenia gravis patients seen during the same time and 37 percent of myasthenic patients with thymomas. Eight are still alive and 11 have died. Fifteen patients had the onset of myasthenic symptoms before discovery of the thymoma, while only four patients had chest symptoms and/or radiographic evidence of an anterior mediastinal mass prior to the onset of weakness. Radical excision of the tumor, if possible, and the remaining thymus, high dosage alternate day prednisone, and radiation therapy, if indicated, seem the treatments of choice. Recurrences of tumor nodules may necessitate further local radiation or the use of cytotoxic agents.
Authors:
A J Goldman; C Herrmann; J C Keesey; D G Mulder; W J Brown
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Neurology     Volume:  25     ISSN:  0028-3878     ISO Abbreviation:  Neurology     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-02-02     Completed Date:  1976-02-02     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0401060     Medline TA:  Neurology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1021-5     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Chlorambucil / therapeutic use
Cyclophosphamide / therapeutic use
Female
Humans
Male
Middle Aged
Myasthenia Gravis / complications*
Neoplasm Recurrence, Local
Neostigmine / therapeutic use
Prednisone / therapeutic use
Pyridostigmine Bromide / therapeutic use
Thymectomy
Thymoma / complications*,  therapy
Thymus Neoplasms / complications*,  therapy
Chemical
Reg. No./Substance:
101-26-8/Pyridostigmine Bromide; 305-03-3/Chlorambucil; 50-18-0/Cyclophosphamide; 53-03-2/Prednisone; 59-99-4/Neostigmine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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