Document Detail

Myasthenia gravis in a collegiate football player.
MedLine Citation:
PMID:  11128838     Owner:  NLM     Status:  MEDLINE    
A 17-yr-old Division I-AA collegiate offensive lineman developed unilateral ptosis shortly after minor head trauma during a scrimmage. The subsequent temporal profile of the ptosis, a history of a similar event lasting a short period of time 2 yr earlier, and the results of his clinical and electrophysiologic examinations established a diagnosis of very mild, generalized, antibody-negative myasthenia gravis (MG). His desire to continue playing football posed several additional management problems for which there was no published guidance. We started him on alternate-day, high-dose prednisone therapy with potassium and calcium supplementation, and allowed him to partake in conditioning but no contact. Except for residual decreased exercise tolerance, he improved symptomatically and experienced no serious adverse effects from the illness or the treatment during his first season, despite imperfect drug compliance. His MG eventually came under excellent symptomatic control, allowing initiation of a slow taper of the prednisone before his second season. Shortly thereafter, he abruptly stopped the prednisone without seeking medical advice. He continued to experience mild left ptosis and a mild decrease in intense exercise tolerance. He decided to forego his senior season of collegiate football after a bout of severe mechanical low-back pain incurred during spring football practice and limited his athletic activity thereafter to recreational sports.
J J Leddy; J G Chutkow
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Medicine and science in sports and exercise     Volume:  32     ISSN:  0195-9131     ISO Abbreviation:  Med Sci Sports Exerc     Publication Date:  2000 Dec 
Date Detail:
Created Date:  2000-12-20     Completed Date:  2001-04-12     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8005433     Medline TA:  Med Sci Sports Exerc     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1975-9     Citation Subset:  IM; S    
Department of Orthopaedics and Neurology and the Sports Medicine Institute, State University of New York at Buffalo, School of Medicine and Biomedical Sciences, USA.
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MeSH Terms
Athletic Injuries / complications
Blepharoptosis / etiology
Football* / injuries
Glucocorticoids / therapeutic use
Myasthenia Gravis / diagnosis,  drug therapy,  therapy*
Prednisone / therapeutic use
Reg. No./Substance:
0/Glucocorticoids; 53-03-2/Prednisone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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