Document Detail

Myasthenia gravis in children and its anaesthetic implications.
MedLine Citation:
PMID:  2268010     Owner:  NLM     Status:  MEDLINE    
Myasthenia gravis, a rare disease in children, occurs in a variety of forms. The aetiology and clinical presentations are reviewed. Eight patients who were studied with electromyography are presented. The results show that, in general, patients with the usual pattern of disease are resistant to suxamethonium (ED95 3-4 times normal) and are sensitive to nondepolarizing relaxants. When the latter are used it is advisable to administer small increments with neuromuscular monitoring. One patient with the disease localised to the eyelid had normal EMG responses when monitored on the hand with ulnar nerve stimulation.
T C Brown; R Gebert; O A Meretoja; L K Shield
Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Anaesthesia and intensive care     Volume:  18     ISSN:  0310-057X     ISO Abbreviation:  Anaesth Intensive Care     Publication Date:  1990 Nov 
Date Detail:
Created Date:  1991-02-08     Completed Date:  1991-02-08     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  0342017     Medline TA:  Anaesth Intensive Care     Country:  AUSTRALIA    
Other Details:
Languages:  eng     Pagination:  466-72     Citation Subset:  IM    
Royal Children's Hospital, Melbourne, Australia.
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MeSH Terms
Anesthesia, General*
Child, Preschool
Infant, Newborn
Myasthenia Gravis / physiopathology*
Neuromuscular Blocking Agents / pharmacology*
Neuromuscular Junction / drug effects,  physiology
Reg. No./Substance:
0/Neuromuscular Blocking Agents

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