Document Detail


Myasthenia gravis in Hong Kong Chinese. 1. Epidemiology and adult disease.
MedLine Citation:
PMID:  1414218     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A territory-wide study of myasthenia gravis (MG) was conducted in Hong Kong. Two hundred and sixty-two Chinese patients (159 adult and 103 paediatric onset) were identified, corresponding to a point prevalence and period prevalence of 53.5 and 62.2 per million respectively, and an average annual incidence of 4.0 per million population. Nine patients died, 7 from MG, giving a case fatality rate of 0.027. Female predominance was present in the whole group of patients (female to male ratio 1.6:1) and in those with adult disease (ratio 2.1:1), but not in those with onset in childhood (ration 1.1:1). Onset of disease was most common in the first 3 decades of life, and became less common in subsequent decades. Juvenile onset MG occurred in 39.3% of patients and restricted ocular MG in 47.9%. Familial occurrence was found in 5 patients. In the 159 adult onset patients, ocular disease was most common (32.7%), followed by mild generalised (29.6%), moderately severe generalised (24.5%), fulminating (11.9%) and late severe disease (1.3%). The mean age of onset of symptoms was 36.7 years. The symptomatology was similar to that of Caucasoid populations. Autoimmune thyroid disease was the commonest associated disease, and the incidence of thymoma among thymic abnormalities was high at 38%.
Authors:
Y L Yu; B R Hawkins; M S Ip; V Wong; E Woo
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta neurologica Scandinavica     Volume:  86     ISSN:  0001-6314     ISO Abbreviation:  Acta Neurol. Scand.     Publication Date:  1992 Aug 
Date Detail:
Created Date:  1992-10-29     Completed Date:  1992-10-29     Revised Date:  2006-08-16    
Medline Journal Info:
Nlm Unique ID:  0370336     Medline TA:  Acta Neurol Scand     Country:  DENMARK    
Other Details:
Languages:  eng     Pagination:  113-9     Citation Subset:  IM    
Affiliation:
Department of Medicine, Queen Mary Hospital, University of Hong Kong.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Child
Child, Preschool
Cross-Sectional Studies
Ethnic Groups / statistics & numerical data*
Female
Gene Frequency / genetics
HLA-B Antigens / genetics
Hong Kong / epidemiology
Humans
Incidence
Infant
Male
Middle Aged
Myasthenia Gravis / diagnosis,  epidemiology*,  genetics
Neurologic Examination
Risk Factors
Thymoma / diagnosis,  epidemiology,  genetics
Thymus Neoplasms / diagnosis,  epidemiology,  genetics
Chemical
Reg. No./Substance:
0/HLA-B Antigens; 0/HLA-Bw46

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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