Document Detail

Myasthenia gravis associated with penicillamine treatment for rheumatoid arthritis.
MedLine Citation:
PMID:  1125624     Owner:  NLM     Status:  MEDLINE    
Four patients with rheumatoid arthritis (R.A.) developed myasthenia gravis after taking penicillamine. In one patient withdrawal of the drug was followed by spontaneous remission of the myasthenia, and in two the dose of anticholinesterase was subsequently reduced. In the fourth patient continuing penicillamine treatment was associated with increasingly severe myasthenic features, but on withdrawal of the drug these resolved. As myasthenia gravis rarely complicates R.A. its onset in these patients shortly after the start of penicillamine treatment suggested that penicillamine may have precipitated this condition.
R C Bucknall; J Dixon A St; E N Glick; J Woodland; D W Zutshi
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  British medical journal     Volume:  1     ISSN:  0007-1447     ISO Abbreviation:  Br Med J     Publication Date:  1975 Mar 
Date Detail:
Created Date:  1975-07-14     Completed Date:  1975-07-14     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  0372673     Medline TA:  Br Med J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  600-2     Citation Subset:  AIM; IM    
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MeSH Terms
Arthritis, Rheumatoid / complications,  drug therapy
Cholinesterase Inhibitors / therapeutic use
Middle Aged
Myasthenia Gravis / chemically induced*,  complications,  drug therapy
Penicillamine / adverse effects*,  therapeutic use
Reg. No./Substance:
0/Cholinesterase Inhibitors; 52-67-5/Penicillamine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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