| Myasthenia gravis (MG) treatment with immunoadsorbent columns. | |
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MedLine Citation:
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PMID: 1751675 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We performed ten plasma perfusion (PP) treatments on eight patients affected by Myasthenia Gravis (MG) with high serum levels of autoantibodies against acetylcholine receptors (anti AChR-AB), and one PP treatment on a patient with MG of probable genetic origin and without specific antibodies. All patients (Osserman group III-IV) had undergone thymectomy and immunosuppressive therapy. Each patient received a treatment cycle of six PP sessions. Clinical conditions were assessed before and after the treatment with evaluation of muscular strength, ventilatory function, and electromyographic testing. Immunologic markers were tested before and after each PP. The patient without specific antibodies showed no improvement with PP and was excluded from our study. All the other patients showed continued improvement, with increased muscle strength and improved respiratory function. Four patients (follow-up 16-24 months) still maintain the clinical improvement; two, unexpectedly relapsed 11-12 months after PP, received a new treatment successfully (follow-up 9-10 month). |
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Authors:
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G Splendiani; S Passalacqua; G Barbera; A Sturniolo; S Costanzi; E Bartoccioni; C U Casciani |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology Volume: 19 ISSN: 1055-7172 ISO Abbreviation: Biomater Artif Cells Immobilization Biotechnol Publication Date: 1991 |
Date Detail:
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Created Date: 1992-01-30 Completed Date: 1992-01-30 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 9111988 Medline TA: Biomater Artif Cells Immobilization Biotechnol Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 255-65 Citation Subset: IM |
Affiliation:
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2d Università Tor Vergata, C.I. Columbus, Roma. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Child Child, Preschool Female Follow-Up Studies Hemoperfusion / adverse effects, methods* Humans Immunosorbents Male Myasthenia Gravis / blood, therapy* Plasma |
| Chemical | |
Reg. No./Substance:
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0/Immunosorbents |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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