Document Detail


Myasthenia gravis (MG) treatment with immunoadsorbent columns.
MedLine Citation:
PMID:  1751675     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We performed ten plasma perfusion (PP) treatments on eight patients affected by Myasthenia Gravis (MG) with high serum levels of autoantibodies against acetylcholine receptors (anti AChR-AB), and one PP treatment on a patient with MG of probable genetic origin and without specific antibodies. All patients (Osserman group III-IV) had undergone thymectomy and immunosuppressive therapy. Each patient received a treatment cycle of six PP sessions. Clinical conditions were assessed before and after the treatment with evaluation of muscular strength, ventilatory function, and electromyographic testing. Immunologic markers were tested before and after each PP. The patient without specific antibodies showed no improvement with PP and was excluded from our study. All the other patients showed continued improvement, with increased muscle strength and improved respiratory function. Four patients (follow-up 16-24 months) still maintain the clinical improvement; two, unexpectedly relapsed 11-12 months after PP, received a new treatment successfully (follow-up 9-10 month).
Authors:
G Splendiani; S Passalacqua; G Barbera; A Sturniolo; S Costanzi; E Bartoccioni; C U Casciani
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Biomaterials, artificial cells, and immobilization biotechnology : official journal of the International Society for Artificial Cells and Immobilization Biotechnology     Volume:  19     ISSN:  1055-7172     ISO Abbreviation:  Biomater Artif Cells Immobilization Biotechnol     Publication Date:  1991  
Date Detail:
Created Date:  1992-01-30     Completed Date:  1992-01-30     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9111988     Medline TA:  Biomater Artif Cells Immobilization Biotechnol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  255-65     Citation Subset:  IM    
Affiliation:
2d Università Tor Vergata, C.I. Columbus, Roma.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Child
Child, Preschool
Female
Follow-Up Studies
Hemoperfusion / adverse effects,  methods*
Humans
Immunosorbents
Male
Myasthenia Gravis / blood,  therapy*
Plasma
Chemical
Reg. No./Substance:
0/Immunosorbents

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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