| Myasthenia gravis and HLA phenotypes in Jamaicans. | |
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MedLine Citation:
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PMID: 1523452 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We determined HLA-antigen frequencies and corresponding relative risks (RR) in 30 Jamaicans with myasthenia gravis (MG) and 40 normal controls. Using a microcytotoxicity assay and commercially prepared typing trays, we found that the strongest HLA associations with MG in Jamaicans were with HLA-A2 (RR = 6.15), HLA-B8 (RR = 3.4), HLA-B13 (RR = 7.76), and DQw4 (RR = 3.8). After correction of the P value for the number of antigens tested, only HLA-A2 was statistically significantly increased in MG patients. There was a statistically significant negative association between MG and HLA-DR2, as well as HLA-A9 and -B5. No correlation was observed between HLA phenotype, thymic disease, clinical grades, or disease course. HLA-A2 and sex were independent risk factors for MG, female patients having a higher risk (RR = 5.8). Further studies using larger patient and control groups, locally derived typing sera, and DNA probe analysis are indicated. |
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Authors:
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E N Barton; M Smikle; O S Morgan |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Southern medical journal Volume: 85 ISSN: 0038-4348 ISO Abbreviation: South. Med. J. Publication Date: 1992 Sep |
Date Detail:
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Created Date: 1992-10-15 Completed Date: 1992-10-15 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0404522 Medline TA: South Med J Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 904-6 Citation Subset: AIM; IM |
Affiliation:
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Department of Medicine, University Hospital of the West Indies, Mona, Kingston, Jamaica. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adolescent Adult Aged Aged, 80 and over Child Cytotoxicity Tests, Immunologic Ethnic Groups / genetics Female Gene Frequency* HLA Antigens / genetics* HLA-A2 Antigen / genetics Histocompatibility Testing Hospitals, University Humans Jamaica / epidemiology Logistic Models Male Middle Aged Myasthenia Gravis / epidemiology, genetics* Phenotype Risk Factors Sex Factors |
| Chemical | |
Reg. No./Substance:
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0/HLA Antigens; 0/HLA-A2 Antigen |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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