Document Detail


Myasthenia gravis and HLA phenotypes in Jamaicans.
MedLine Citation:
PMID:  1523452     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We determined HLA-antigen frequencies and corresponding relative risks (RR) in 30 Jamaicans with myasthenia gravis (MG) and 40 normal controls. Using a microcytotoxicity assay and commercially prepared typing trays, we found that the strongest HLA associations with MG in Jamaicans were with HLA-A2 (RR = 6.15), HLA-B8 (RR = 3.4), HLA-B13 (RR = 7.76), and DQw4 (RR = 3.8). After correction of the P value for the number of antigens tested, only HLA-A2 was statistically significantly increased in MG patients. There was a statistically significant negative association between MG and HLA-DR2, as well as HLA-A9 and -B5. No correlation was observed between HLA phenotype, thymic disease, clinical grades, or disease course. HLA-A2 and sex were independent risk factors for MG, female patients having a higher risk (RR = 5.8). Further studies using larger patient and control groups, locally derived typing sera, and DNA probe analysis are indicated.
Authors:
E N Barton; M Smikle; O S Morgan
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Southern medical journal     Volume:  85     ISSN:  0038-4348     ISO Abbreviation:  South. Med. J.     Publication Date:  1992 Sep 
Date Detail:
Created Date:  1992-10-15     Completed Date:  1992-10-15     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0404522     Medline TA:  South Med J     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  904-6     Citation Subset:  AIM; IM    
Affiliation:
Department of Medicine, University Hospital of the West Indies, Mona, Kingston, Jamaica.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Aged, 80 and over
Child
Cytotoxicity Tests, Immunologic
Ethnic Groups / genetics
Female
Gene Frequency*
HLA Antigens / genetics*
HLA-A2 Antigen / genetics
Histocompatibility Testing
Hospitals, University
Humans
Jamaica / epidemiology
Logistic Models
Male
Middle Aged
Myasthenia Gravis / epidemiology,  genetics*
Phenotype
Risk Factors
Sex Factors
Chemical
Reg. No./Substance:
0/HLA Antigens; 0/HLA-A2 Antigen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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