Document Detail


MxA protein induction in MS patients treated with intramuscular IFNbeta-1a.
MedLine Citation:
PMID:  16601938     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
MxA protein production in peripheral blood leukocytes is a valuable marker to evaluate biologic effects of interferon-beta (IFNbeta) therapy in multiple sclerosis (MS) patients. The three IFNbeta preparations available in the treatment of MS differ with respect to antigenicity and biologic activity. We studied prospectively the induction of MxA protein and the development of binding (BAb) and neutralising antibodies (NAb) in nine relapsing-remitting MS (RRMS) patients during one year of intramuscular IFNbeta -1a (Avonex) treatment. Another nine RRMS patient treated with Avonex for 1-3.5 years were also included. The results were compared with our earlier published data of subcutaneous IFNbeta-1a (Rebif). None of these 18 patients developed NAb but three of the long-term patients developed BAb. The baseline MxA protein levels rose but the induction was weaker compared to Rebif. The stimulation index (MxA after/before IFNbeta-1a injection) remained elevated. Weekly intramuscular dosing of IFNbeta-1a provides a sustained effect on lymphocytes but differences in leukocyte stimulation may underlie some of the differences between IFNbeta therapies.
Authors:
A M Vallittu; A A Salmi; J P Erälinna;
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology     Volume:  26     ISSN:  1590-1874     ISO Abbreviation:  Neurol. Sci.     Publication Date:  2006 Feb 
Date Detail:
Created Date:  2006-04-07     Completed Date:  2006-09-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  100959175     Medline TA:  Neurol Sci     Country:  Italy    
Other Details:
Languages:  eng     Pagination:  438-43     Citation Subset:  IM    
Affiliation:
Department of Virology, University of Turku, Finland. anna-maija.vallittu@utu.fi
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MeSH Terms
Descriptor/Qualifier:
Adjuvants, Immunologic / administration & dosage*
Adult
Disability Evaluation
Female
Flow Cytometry / methods
Follow-Up Studies
GTP-Binding Proteins / blood*
Gene Expression / drug effects*
Humans
Injections, Intramuscular / methods
Interferon-beta / administration & dosage*
Male
Middle Aged
Multiple Sclerosis / drug therapy,  metabolism*
Chemical
Reg. No./Substance:
0/Adjuvants, Immunologic; 0/myxovirus resistance proteins; 77238-31-4/Interferon-beta; EC 3.6.1.-/GTP-Binding Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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