| Muzolimine in advanced chronic renal failure. | |
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MedLine Citation:
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PMID: 4002783 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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27 patients with creatinine clearances ranging from 20 to 2 ml/min were treated daily with 6.9 mg/kg of muzolimine, for 10 to 25 days. The hyperhydration state with oedema decreased gradually in all patients without hypotensive phenomena. Muzolimine benefited hypertension in patients with expansion of the extracellular space and it also strengthened the effect of clonidine or minoxidil. Important diuretic and natriuretic effects were obtained. Metabolic acidosis improved. No subjective adverse reactions to the drug or side effects were noted. High-dose muzolimine appears to be efficacious and safe for short-term treatment in patients with severe chronic renal failure. |
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Authors:
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F Mastrangelo; S Rizzelli; C Corlianò; L Alfonso; V De Blasi; M Aprile; A M Montinaro; M Napoli |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Zeitschrift für Kardiologie Volume: 74 Suppl 2 ISSN: 0300-5860 ISO Abbreviation: Z Kardiol Publication Date: 1985 |
Date Detail:
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Created Date: 1985-07-25 Completed Date: 1985-07-25 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0360430 Medline TA: Z Kardiol Country: GERMANY, WEST |
Other Details:
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Languages: eng Pagination: 109-14 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acid-Base Imbalance
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drug therapy Acidosis / drug therapy Adult Aged Clonidine / therapeutic use Diuresis / drug effects Edema / drug therapy Female Glomerular Filtration Rate Humans Hypertension / drug therapy Kidney Failure, Chronic / drug therapy*, physiopathology Male Middle Aged Muzolimine / adverse effects, therapeutic use* Natriuresis / drug effects Pyrazoles / therapeutic use* |
| Chemical | |
Reg. No./Substance:
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0/Pyrazoles; 4205-90-7/Clonidine; 55294-15-0/Muzolimine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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