Document Detail

Mutual information based CT registration of the lung at exhale and inhale breathing states using thin-plate splines.
MedLine Citation:
PMID:  15587645     Owner:  NLM     Status:  MEDLINE    
The advent of dynamic radiotherapy modeling and treatment techniques requires an infrastructure to weigh the merits of various interventions (breath holding, gating, tracking). The creation of treatment planning models that account for motion and deformation can allow the relative worth of such techniques to be evaluated. In order to develop a treatment planning model of a moving and deforming organ such as the lung, registration tools that account for deformation are required. We tested the accuracy of a mutual information based image registration tool using thin-plate splines driven by the selection of control points and iterative alignment according to a simplex algorithm. Eleven patients each had sequential CT scans at breath-held normal inhale and exhale states. The exhale right lung was segmented from CT and served as the reference model. For each patient, thirty control points were used to align the inhale CT right lung to the exhale CT right lung. Alignment accuracy (the standard deviation of the difference in the actual and predicted inhale position) was determined from locations of vascular and bronchial bifurcations, and found to be 1.7, 3.1, and 3.6 mm about the RL, AP, and IS directions. The alignment accuracy was significantly different from the amount of measured movement during breathing only in the AP and IS directions. The accuracy of alignment including thin-plate splines was more accurate than using affine transformations and the same iteration and scoring methodology. This technique shows promise for the future development of dynamic models of the lung for use in four-dimensional (4-D) treatment planning.
Martha M Coselmon; James M Balter; Daniel L McShan; Marc L Kessler
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Publication Detail:
Type:  Clinical Trial; Comparative Study; Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Medical physics     Volume:  31     ISSN:  0094-2405     ISO Abbreviation:  Med Phys     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-12-13     Completed Date:  2005-03-31     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  0425746     Medline TA:  Med Phys     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2942-8     Citation Subset:  IM    
Department of Radiation Oncology, University of Michigan, Ann Arbor, Michigan 48109, USA.
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MeSH Terms
Exhalation / physiology
Imaging, Three-Dimensional / methods
Information Storage and Retrieval / methods
Inhalation / physiology
Lung / physiology*,  radiography*
Movement / physiology
Numerical Analysis, Computer-Assisted
Radiographic Image Enhancement / methods*
Radiographic Image Interpretation, Computer-Assisted / methods*
Reproducibility of Results
Respiratory Mechanics / physiology*
Sensitivity and Specificity
Subtraction Technique*
Tomography, Spiral Computed / methods*
Grant Support

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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