Document Detail

Mutual antagonism between signals secreted by adjacent wingless and engrailed cells leads to specification of complementary regions of the Drosophila parasegment.
MedLine Citation:
PMID:  10457019     Owner:  NLM     Status:  MEDLINE    
Specialized groups of cells known as organizers govern the establishment of cell type diversity across cellular fields. Segmental patterning within the Drosophila embryonic epidermis is one paradigm for organizer function. Here cells differentiate into smooth cuticle or distinct denticle types. At parasegment boundaries, cells expressing Wingless confront cells co-expressing Engrailed and Hedgehog. While Wingless is essential for smooth cell fates, the signals that establish denticle diversity are unknown. We show that wg mutants have residual mirror-symmetric pattern that is due to an Engrailed-dependent signal specifying anterior denticle fates. The Engrailed-dependent signal acts unidirectionally and Wg activity imposes this asymmetry. Reciprocally, the Engrailed/Hedgehog interface imposes asymmetry on Wg signaling. Thus, a bipartite organizer, with each signal acting essentially unidirectionally, specifies segmental pattern.
U Gritzan; V Hatini; S DiNardo
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Development (Cambridge, England)     Volume:  126     ISSN:  0950-1991     ISO Abbreviation:  Development     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-21     Completed Date:  1999-10-21     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8701744     Medline TA:  Development     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  4107-15     Citation Subset:  IM    
Cell & Developmental Biology, University of Pennsylvania Medical School, Philadelphia, PA 19104, USA.
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MeSH Terms
Body Patterning / genetics
Calcium-Binding Proteins
Cell Differentiation
Drosophila / embryology*,  genetics
Drosophila Proteins*
Embryo, Nonmammalian
Embryonic Induction
Gene Expression Regulation, Developmental*
Hedgehog Proteins
Homeodomain Proteins / genetics,  metabolism*
Insect Proteins / genetics,  metabolism
Intercellular Signaling Peptides and Proteins
Membrane Proteins / genetics,  metabolism
Proto-Oncogene Proteins / genetics,  metabolism*
Signal Transduction
Transcription Factors / genetics,  metabolism*
Wnt1 Protein
Grant Support
Reg. No./Substance:
0/Calcium-Binding Proteins; 0/Drosophila Proteins; 0/Hedgehog Proteins; 0/Homeodomain Proteins; 0/Insect Proteins; 0/Intercellular Signaling Peptides and Proteins; 0/Membrane Proteins; 0/Proto-Oncogene Proteins; 0/Rho protein, Drosophila; 0/Transcription Factors; 0/Wnt1 Protein; 0/engrail protein, Drosophila; 0/rho-2 protein, Drosophila; 0/wg protein, Drosophila; 134324-36-0/Serrate proteins; 149291-21-4/hedgehog protein, Drosophila

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