Document Detail

Mutilating palmoplantar keratoderma successfully treated with etretinate.
MedLine Citation:
PMID:  6084939     Owner:  NLM     Status:  MEDLINE    
Three patients, a mother and her two sons, with mutilating palmoplantar keratoderma (Vohwinkel's syndrome) were successfully treated with oral etretinate (Tigason). All of them had keratotic constriction furrows of one or more digits (pseudo-ainhum) with threatening spontaneous amputation. Oral treatment with etretinate brought about disappearance of the pseudo-ainhums and normalization of the digital blood circulation. The hyperkeratotic skin became thinned and pliable with a dose-dependent trend towards redness and atrophy. Continued long term etretinate medication has made it possible for these patients to fulfill their social and occupational activities. All 3 patients had acoustic impairment of high-pitched tone perception.
K Wereide
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Acta dermato-venereologica     Volume:  64     ISSN:  0001-5555     ISO Abbreviation:  Acta Derm. Venereol.     Publication Date:  1984  
Date Detail:
Created Date:  1985-04-10     Completed Date:  1985-04-10     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0370310     Medline TA:  Acta Derm Venereol     Country:  SWEDEN    
Other Details:
Languages:  eng     Pagination:  566-9     Citation Subset:  IM    
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MeSH Terms
Etretinate / therapeutic use*
Fingers / pathology
Hearing Loss, High-Frequency / etiology
Keratoderma, Palmoplantar / drug therapy,  genetics*,  pathology
Middle Aged
Skin / pathology
Reg. No./Substance:

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