| Mutations in the ras proto-oncogenes in patients with myelodysplastic syndromes. | |
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MedLine Citation:
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PMID: 7512175 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Activation of the N- and K-ras proto-oncogenes is the most common molecular abnormality in myelodysplastic syndromes (MDS) and acute myeloid leukemia (AML). In retrospective studies, approximately 3-36% of MDS patients were reported to harbor a mutated ras proto-oncogene, with some series suggesting the presence of ras-mutations are associated with progressive disease and a poor prognosis. Since hematopoietic growth factors such as granulocyte colony-stimulating factor (G-CSF) are currently used for therapy in MDS but may stimulate the proliferation of leukemic cells, we assessed the frequency and significance of ras mutations in 27 MDS patients, 15 of whom underwent G-CSF therapy. Patients were analyzed for the presence of mutations in codons 12, 13, and 61 of the N- and K-ras proto-oncogenes. Only three patients (11%, two refractory anemia with excess of blasts (RAEB), one RAEB in transformation (RAEB-T)) harbored activated ras oncogenes with the mutations localized in N-ras codons 12 and 61. Patients were followed for periods of up to 4 years or until death supervened. Patients exhibiting ras mutations were no more likely to develop AML compared to ras-negative patients (1/3 vs. 10/24) or to have decreased survival (p = 0.64). These data indicate that, in this group of MDS patients, ras mutations do not appear to correlate with a poor prognosis, and do not adversely interact with exogenously administered G-CSF. |
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Authors:
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A Neubauer; P Greenberg; R Negrin; N Ginzton; E Liu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Leukemia Volume: 8 ISSN: 0887-6924 ISO Abbreviation: Leukemia Publication Date: 1994 Apr |
Date Detail:
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Created Date: 1994-05-10 Completed Date: 1994-05-10 Revised Date: 2013-03-04 |
Medline Journal Info:
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Nlm Unique ID: 8704895 Medline TA: Leukemia Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 638-41 Citation Subset: IM |
Affiliation:
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Department of Medicine and Genetics, Lineberger Cancer Research Center, University of North Carolina at Chapel Hill. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Anemia, Refractory / genetics Anemia, Refractory, with Excess of Blasts / genetics, therapy Codon / genetics Genes, ras / genetics* Granulocyte Colony-Stimulating Factor / therapeutic use Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use Humans Leukemia, Myeloid / genetics, therapy Mutation / genetics* Myelodysplastic Syndromes / genetics*, therapy |
| Grant Support | |
ID/Acronym/Agency:
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R01-CA36915/CA/NCI NIH HHS; R01-CA49240-01/CA/NCI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Codon; 143011-72-7/Granulocyte Colony-Stimulating Factor; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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