Document Detail

Mutations in rDNA : 3. Modulatory action of α-amanitin on aberration induction in nucleolus organizer regions.
MedLine Citation:
PMID:  24254177     Owner:  NLM     Status:  In-Data-Review    
The action of α-amanitin, an inhibitor of RNA synthesis, on the induction by hydroxyurea (HU) of chromosomal aberrations in nucleolus organizer regions of barley was studied. The data obtained show that α-amanitin can effectively modify aberration induction in rDNA. Administered before mutagen treatment or in combination with the mutagen, the toxin significantly decreased the HU-induced aberration frequencies in NORs. The data obtained provide further evidence that α-amanitin is an effective modulator of aberration induction in NORs either by interfering with RNA synthesis or by modifying chromatin structure.
H Nicoloff; R Rieger
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  TAG. Theoretical and applied genetics. Theoretische und angewandte Genetik     Volume:  70     ISSN:  0040-5752     ISO Abbreviation:  Theor. Appl. Genet.     Publication Date:  1985 May 
Date Detail:
Created Date:  2013-11-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0145600     Medline TA:  Theor Appl Genet     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  178-84     Citation Subset:  -    
Zentralinstitut für Genetik und Kulturpflanzenforschung, DDR-4325, Gatersleben, German Democratic Republic.
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