Document Detail

Mutations in the neverland gene turned Drosophila pachea into an obligate specialist species.
MedLine Citation:
PMID:  23019649     Owner:  NLM     Status:  In-Process    
Most living species exploit a limited range of resources. However, little is known about how tight associations build up during evolution between such specialist species and the hosts they use. We examined the dependence of Drosophila pachea on its single host, the senita cactus. Several amino acid changes in the Neverland oxygenase rendered D. pachea unable to transform cholesterol into 7-dehydrocholesterol (the first reaction in the steroid hormone biosynthetic pathway in insects) and thus made D. pachea dependent on the uncommon sterols of its host plant. The neverland mutations increase survival on the cactus's unusual sterols and are in a genomic region that faced recent positive selection. This study illustrates how relatively few genetic changes in a single gene may restrict the ecological niche of a species.
Michael Lang; Sophie Murat; Andrew G Clark; Géraldine Gouppil; Catherine Blais; Luciano M Matzkin; Emilie Guittard; Takuji Yoshiyama-Yanagawa; Hiroshi Kataoka; Ryusuke Niwa; René Lafont; Chantal Dauphin-Villemant; Virginie Orgogozo
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Science (New York, N.Y.)     Volume:  337     ISSN:  1095-9203     ISO Abbreviation:  Science     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-09-28     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0404511     Medline TA:  Science     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1658-61     Citation Subset:  IM    
CNRS UMR7592, Université Paris Diderot, Sorbonne Paris Cité, Institut Jacques Monod, Paris, France.
Data Bank Information
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