| Mutations around interferon sensitivity-determining region: a pilot resistance report of hepatitis C virus 1b in a Hong Kong population. | |
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MedLine Citation:
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PMID: 22219602 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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AIM: To explore mutations around the interferon sensitivity-determining region (ISDR) which are associated with the resistance of hepatitis C virus 1b (HCV-1b) to interferon-α treatment. METHODS: Thirty-seven HCV-1b samples were obtained from Hong Kong patients who had completed the combined interferon-α/ribavirin treatment for more than one year with available response data. Nineteen of them were sustained virological responders, while 18 were non-responders. The amino acid sequences of the extended ISDR (eISDR) covering 64 amino acids upstream and 67 amino acids downstream from the previously reported ISDR were analyzed. RESULTS: One amino acid variation (I2268V, P = 0.023) was significantly correlated with treatment outcome in this pilot study with a limited number of patients, while two amino acid variations (R2260H, P = 0.05 and S2278T, P = 0.05) were weakly associated with treatment outcome. The extent of amino acid variations within the ISDR or eISDR was not correlated with treatment outcome as previously reported. CONCLUSION: Three amino acid mutations near but outside of ISDR may associate with interferon treatment resistance of HCV-1b patients in Hong Kong. |
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Authors:
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Xiao-Ming Zhou; Paul Ks Chan; John S Tam |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: World journal of gastroenterology : WJG Volume: 17 ISSN: 1007-9327 ISO Abbreviation: World J. Gastroenterol. Publication Date: 2011 Dec |
Date Detail:
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Created Date: 2012-01-05 Completed Date: 2012-03-02 Revised Date: 2013-05-29 |
Medline Journal Info:
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Nlm Unique ID: 100883448 Medline TA: World J Gastroenterol Country: China |
Other Details:
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Languages: eng Pagination: 5317-23 Citation Subset: IM |
Affiliation:
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Department of Epidemiology, Shanghai Public Health Clinical Center, Fudan University, Shanghai 201508, China. xmzhou@shmu.edu.cn |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Amino Acid Sequence Amino Acid Substitution Antiviral Agents / pharmacology, therapeutic use* Drug Resistance, Viral / genetics* Female Hepacivirus / drug effects, genetics*, physiology* Hepatitis C, Chronic / drug therapy*, genetics Hong Kong Humans Interferon-alpha / pharmacology, therapeutic use* Male Middle Aged Molecular Sequence Data Mutation* Pilot Projects Sequence Alignment Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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0/Antiviral Agents; 0/Interferon-alpha |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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