Document Detail


Mutations around interferon sensitivity-determining region: a pilot resistance report of hepatitis C virus 1b in a Hong Kong population.
MedLine Citation:
PMID:  22219602     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
AIM: To explore mutations around the interferon sensitivity-determining region (ISDR) which are associated with the resistance of hepatitis C virus 1b (HCV-1b) to interferon-α treatment.
METHODS: Thirty-seven HCV-1b samples were obtained from Hong Kong patients who had completed the combined interferon-α/ribavirin treatment for more than one year with available response data. Nineteen of them were sustained virological responders, while 18 were non-responders. The amino acid sequences of the extended ISDR (eISDR) covering 64 amino acids upstream and 67 amino acids downstream from the previously reported ISDR were analyzed.
RESULTS: One amino acid variation (I2268V, P = 0.023) was significantly correlated with treatment outcome in this pilot study with a limited number of patients, while two amino acid variations (R2260H, P = 0.05 and S2278T, P = 0.05) were weakly associated with treatment outcome. The extent of amino acid variations within the ISDR or eISDR was not correlated with treatment outcome as previously reported.
CONCLUSION: Three amino acid mutations near but outside of ISDR may associate with interferon treatment resistance of HCV-1b patients in Hong Kong.
Authors:
Xiao-Ming Zhou; Paul Ks Chan; John S Tam
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  World journal of gastroenterology : WJG     Volume:  17     ISSN:  2219-2840     ISO Abbreviation:  World J. Gastroenterol.     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2012-01-05     Completed Date:  2012-03-02     Revised Date:  2014-05-20    
Medline Journal Info:
Nlm Unique ID:  100883448     Medline TA:  World J Gastroenterol     Country:  China    
Other Details:
Languages:  eng     Pagination:  5317-23     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Amino Acid Sequence
Amino Acid Substitution
Antiviral Agents / pharmacology,  therapeutic use*
Drug Resistance, Viral / genetics*
Female
Hepacivirus / drug effects,  genetics*,  physiology*
Hepatitis C, Chronic / drug therapy*,  genetics
Hong Kong
Humans
Interferon-alpha / pharmacology,  therapeutic use*
Male
Middle Aged
Molecular Sequence Data
Mutation*
Pilot Projects
Sequence Alignment
Treatment Outcome
Chemical
Reg. No./Substance:
0/Antiviral Agents; 0/Interferon-alpha
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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