Document Detail


Mutational responses of insects in the Biosatellite II experiment.
MedLine Citation:
PMID:  11949689     Owner:  NASA     Status:  MEDLINE    
Abstract/OtherAbstract:
Genetic effects associated with space flight include mutation induction by the space flight itself, and enhancements or antagonisms of radiation-induced mutations. The conditions of space flight vary in mutagenic effectiveness from no response at all to responses nine times that found in ground-based controls. The test systems follow the sensitivity pattern: spermatogonial translocations > oogonial and oocyte nondisjunction > recessive lethality of stages in spermatogenesis > dominant lethality of stages in spermatogenesis. Large enhancing and antagonistic effects of space flight in conjunction with radiation were observed in the Biosatellite II experiment. The most surprising one was the elimination of the effect of 2500 R by space flight in Habrobracon oogonia where the effects of 500 R normally can be easily observed. Two sets of parameters are considered in attempts to explain the responses: (1) the nature of the biological targets, and (2) the particular conditions of space flight that are responsible for the effects.
Authors:
R C von Borstel; R H Smith; A R Whiting; D S Grosch; L S Browning; I I Oster; J V Slater; B Buckhold
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Life sciences and space research     Volume:  7     ISSN:  0075-9422     ISO Abbreviation:  Life Sci Space Res     Publication Date:  1969  
Date Detail:
Created Date:  2002-04-11     Completed Date:  2002-04-18     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1250331     Medline TA:  Life Sci Space Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  70-6     Citation Subset:  S    
Affiliation:
Biology Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.
Space Flight Mission:
Biosatellite 2 Project; Flight Experiment; short duration; unmanned
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MeSH Terms
Descriptor/Qualifier:
Animals
Cosmic Radiation
Dose-Response Relationship, Radiation
Drosophila / genetics*,  growth & development,  radiation effects
Embryo, Nonmammalian / radiation effects
Female
Insects / genetics*,  growth & development,  radiation effects
Male
Mutagenesis*
Oocytes / radiation effects
Prophase
Space Flight*
Species Specificity
Spermatogenesis / radiation effects
Wasps / genetics,  growth & development,  radiation effects
Weightlessness*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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