Document Detail

Mutation processes at human minisatellites.
MedLine Citation:
PMID:  8582338     Owner:  NLM     Status:  MEDLINE    
Minisatellites provide one of the most experimentally tractable systems for studying tandem repeat instability in man. Analysis of mutation processes has been greatly aided by the development of single molecule methods for recovering de novo mutants, and of techniques for exploring allele structure in detail. Application of these approaches to man has shown that minisatellites do not primarily mutate by processes such as replication slippage and unequal crossover intrinsic to the tandem repeat array. Instead, germline repeat instability is largely regulated by cis-acting elements near the array and involves unexpectedly complex processes of gene conversion, of potential relevance to the biology of meiosis. These processes can be explored both in humans and, in principle, in transgenic mouse models of human repeat instability.
A J Jeffreys; M J Allen; J A Armour; A Collick; Y Dubrova; N Fretwell; T Guram; M Jobling; C A May; D L Neil
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Electrophoresis     Volume:  16     ISSN:  0173-0835     ISO Abbreviation:  Electrophoresis     Publication Date:  1995 Sep 
Date Detail:
Created Date:  1996-03-21     Completed Date:  1996-03-21     Revised Date:  2009-09-29    
Medline Journal Info:
Nlm Unique ID:  8204476     Medline TA:  Electrophoresis     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  1577-85     Citation Subset:  IM    
Department of Genetics, University of Leicester, UK.
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MeSH Terms
Base Sequence
Forensic Medicine / methods*
Genetic Complementation Test
Microsatellite Repeats*
Molecular Sequence Data
Spermatozoa / physiology,  radiation effects
Grant Support
//Wellcome Trust

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