Document Detail

Mutation in the neural cell adhesion molecule interferes with the differentiation of anterior pituitary secretory cells.
MedLine Citation:
PMID:  11694765     Owner:  NLM     Status:  MEDLINE    
The neural cell adhesion molecule (NCAM) and its polysialylated isoform (PSA-NCAM) have been shown to influence the proliferation, differentiation and survival of different cell types. Here, we report the pattern of expression of NCAM and PSA-NCAM in the anterior lobe (AL) of the pituitary gland of the adult mouse. We demonstrate that the majority of cells express NCAM, while PSA-NCAM is retained mostly on corticotropes. Analysis of bromodeoxyuridine (BrdU) incorporation shows that the presence of PSA-NCAM on corticotropes is not related to proliferation but most likely to their functional properties. We subsequently analyzed defects induced by NCAM deficiency in adult NCAM knockout mice. In these mice, all secretory cell types in the AL are present and their distribution within the gland is similar to that in wild-type mice. However, proliferation of AL cells is significantly increased. In particular, more BrdU-positive cells are detected among somatotropes and mammotropes in NCAM-deficient mice. In addition, the percentages of secretory cells are changed: somatotropes are more numerous while the number of corticotropes is reduced. These data demonstrate the involvement of NCAM in the proper generation and/or maintenance of the different cell populations in the AL and suggest the importance of PSA in corticotrope functioning.
O Gubkina; H Cremer; G Rougon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Neuroendocrinology     Volume:  74     ISSN:  0028-3835     ISO Abbreviation:  Neuroendocrinology     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-11-05     Completed Date:  2001-12-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0035665     Medline TA:  Neuroendocrinology     Country:  Switzerland    
Other Details:
Languages:  eng     Pagination:  335-46     Citation Subset:  IM    
Copyright Information:
Copyright 2001 S. Karger AG, Basel
Laboratoire de Génétique et Physiologie de Développement, CNRS 6545, Institut de Biologie de Développement de Marseille, Parc Scientifique de Luminy, F-13288 Marseille Cedex 9, France.
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MeSH Terms
Cell Count
Cell Differentiation / physiology
Growth Hormone / secretion
Mice, Inbred C57BL
Mutation / physiology*
Neural Cell Adhesion Molecule L1*
Neural Cell Adhesion Molecules / deficiency,  genetics*,  metabolism
Pituitary Gland, Anterior / cytology*,  secretion*
Prolactin / secretion
Reference Values
Sialic Acids / metabolism
Reg. No./Substance:
0/Neural Cell Adhesion Molecule L1; 0/Neural Cell Adhesion Molecules; 0/Sialic Acids; 0/polysialyl neural cell adhesion molecule; 9002-62-4/Prolactin; 9002-72-6/Growth Hormone

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