| Mutation in the beta adducin subunit causes tissue-specific damage to myogenic tone. | |
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MedLine Citation:
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PMID: 21150638 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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BACKGROUND: Damage to renal artery myogenic tone is universally associated with progressive kidney damage. Recently, we have observed that mutations in the beta adducin subunit are associated with proteinuria in the Milan rat. Because of the role of adducin as a component of the cytoskeleton we hypothesized that this mutation may be associated with changes in myogenic tone. METHODS AND RESULTS: Congenic rats were generated with beta adducin subunit mutation (NB rats) and compared with a previously studied rat model with alpha adducin subunit mutation (NAs rats). Blood pressure and urinary protein excretion were studied at two time points: 6 weeks and 4 months of age, and at these time points, small renal, middle cerebral and skeletal (cremaster) arteries were isolated and studied using pressure myography. Agonist-induced vasoconstriction was not different between the two groups at any age. However, myogenic tone in renal arteries was significantly damaged in the NB rat compared to its NAs counterpart and this was associated with a decrease in vascular distensibility. There was a smaller reduction in myogenic tone in the middle cerebral arteries from the NB rat, whereas in the skeletal arteries there was no difference between the two strains. In the NB rat, this tissue-specific damage to myogenic tone was associated with progressive proteinuria despite lower blood pressure than the NAs rat. CONCLUSIONS: Mutations in the beta subunit of the adducin protein result in damage to renal artery myogenic tone and this is associated with renal damage as manifest by proteinuria. |
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Authors:
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Kazuhiko Sonoyama; Adam Greenstein; Rosella Micheletti; Patrizia Ferrari; Antonio Schiavone; Reza Aghamohammadzadeh; Sarah Withers; Grazia Tripodi; Mara Ferrandi; Anthony Heagerty |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2010-12-13 |
Journal Detail:
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Title: Journal of hypertension Volume: - ISSN: 1473-5598 ISO Abbreviation: - Publication Date: 2010 Dec |
Date Detail:
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Created Date: 2010-12-16 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8306882 Medline TA: J Hypertens Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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aShimane Prefectural Central Hospital, Shimane, Japan bCardiovascular Research Unit, University of Manchester, Manchester, UK cPrassis Istituto di Richerche Sigma Tau, Settimo Milanese, Italy. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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