Document Detail


Mutation "hot spot" in HLA class I-restricted T cell epitope on hepatitis B surface antigen in chronic carriers and hepatocellular carcinoma.
MedLine Citation:
PMID:  10471398     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Mutations in the human hepatitis B virus (HBV) genome contribute to its escape from host immune surveillance and result in persistent infection. We report the identification of frequent mutations encompassing residues 29 to 53 of the HBV surface antigen in chronic HBV carriers as well as in patients with hepatocellular carcinoma. The location of these mutations, not found in patients with acute hepatitis and vaccinated infants, coincides with a human leukocyte antigen class I-restricted cytotoxic T lymphocyte epitope. Significantly, mutations occur at a higher frequency (83%) compared with those identified on the immunogenic "a" determinant (25%) of the corresponding patients. Our findings therefore suggest the potential importance of this novel mutation "hot spot" in the establishment of chronic HBV infection.
Authors:
W N Chen; C J Oon
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Biochemical and biophysical research communications     Volume:  262     ISSN:  0006-291X     ISO Abbreviation:  Biochem. Biophys. Res. Commun.     Publication Date:  1999 Sep 
Date Detail:
Created Date:  1999-10-07     Completed Date:  1999-10-07     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0372516     Medline TA:  Biochem Biophys Res Commun     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  757-61     Citation Subset:  IM    
Copyright Information:
Copyright 1999 Academic Press.
Affiliation:
Department of Clinical Research, Singapore General Hospital, Outram Road, Republic of Singapore.
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Aged
Amino Acid Sequence
Carcinoma, Hepatocellular / immunology*,  virology
Carrier State / immunology*,  virology
Child
Epitopes / chemistry,  genetics
Female
Genes, MHC Class I*
Genome, Viral
Hepatitis B / immunology*
Hepatitis B Surface Antigens / genetics,  immunology*
Hepatitis B Vaccines
Hepatitis B virus / genetics*,  immunology
Hepatitis B, Chronic / immunology*
Histocompatibility Antigens Class I / immunology*
Humans
Liver Neoplasms / immunology*,  virology
Male
Middle Aged
Molecular Sequence Data
T-Lymphocytes / immunology*
Chemical
Reg. No./Substance:
0/Epitopes; 0/Hepatitis B Surface Antigens; 0/Hepatitis B Vaccines; 0/Histocompatibility Antigens Class I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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