Document Detail

Mutation analysis of the human dystrobrevin-binding protein 1 gene in schizophrenic patients.
MedLine Citation:
PMID:  15374586     Owner:  NLM     Status:  MEDLINE    
Recent molecular genetic studies have reported a positive association of schizophrenia with several single nucleotide polymorphisms (SNPs) and haplotypes from the human dystrobrevin-binding protein 1 (DTNBP1) gene locus on chromosome 6p. This finding suggests that the DTNBP1 gene is likely a susceptible gene for schizophrenia. Because all the SNPs showing positive association with schizophrenia locate at the intronic sequences of the DTNBP1 gene, we set out to search for mutations in the protein-coding sequences and at the 5' promoter region of the DTNBP1 gene to investigate if the DTNBP1 gene is a schizophrenia-susceptible gene. We directly sequenced the cDNA of DTNBP1 gene in 50 schizophrenic patients and the 5' promoter region of the DTNBP1 genomic DNA in 94 schizophrenia patients. No mutations were identified in either the protein-coding sequences or the 5' promoter region of the human DTNBP1 gene in this sample. Thus, in contrast to prior studies reporting positive association of the DTNBP1 gene with schizophrenia in both Irish and German population, our data indicate that the human DTNBP1 is unlikely a major susceptible gene for schizophrenia in Chinese Han patients from Taiwan.
Hsiao-Mei Liao; Chia-Hsiang Chen
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Schizophrenia research     Volume:  71     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2004-09-17     Completed Date:  2005-01-11     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  185-9     Citation Subset:  IM    
Department of Psychiatry, Tzu-Chi General Hospital and Institute of Human Genetics, Tzu-Chi University, Hualien, 970 Taiwan.
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MeSH Terms
Carrier Proteins / genetics*
DNA Mutational Analysis
DNA, Complementary / genetics
Point Mutation / genetics*
Polymerase Chain Reaction
Polymorphism, Genetic / genetics
Promoter Regions, Genetic / genetics
Schizophrenia / genetics*
Reg. No./Substance:
0/Carrier Proteins; 0/DNA, Complementary; 0/DTNBP1 protein, human

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