Document Detail


Mutagenicity tests of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene.
MedLine Citation:
PMID:  10349610     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The mutagenicity of 4-phenyl-1,3-dithia-2-thioxo-cyclopent-4-ene (DT827B) was examined in reverse mutation tests using Salmonella typhimurium and Escherichia coli, in the chromosomal aberration test with Chinese hamster ovary (CHO) cells, and in the micronucleus test using mice bone-marrow. In reverse mutation assay on DT827B according to Ames' method, DT827B was not mutagenic to S. typhimurium or E. coli when tested in dimethylsulfoxide to the limit of its solubility where precipitation occurred. In chromosomal aberration assay using CHO cells, DT827B was not clastogenic to induce structural chromosomal aberration but capable of inducing polyploidy. In micronucleus test, DT827B did not show micronucleus-inducing potential at the maximum dose. In conclusion of the three mutagenicity studies, DT827B was considered to cause no mutagenicity under the conditions used in the present experiments except the increase in polyploidy, which probably is due to a toxic effect of the compound.
Authors:
S Sadanobu; M L Holmstrom; C G Riach; I A Leddy; M Tezuka
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  The Journal of toxicological sciences     Volume:  24     ISSN:  0388-1350     ISO Abbreviation:  J Toxicol Sci     Publication Date:  1999 May 
Date Detail:
Created Date:  1999-07-20     Completed Date:  1999-07-20     Revised Date:  2005-11-17    
Medline Journal Info:
Nlm Unique ID:  7805798     Medline TA:  J Toxicol Sci     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  87-94     Citation Subset:  IM    
Affiliation:
Department of Hygienic Chemistry, College of Pharmacy, Nihon University, Chiba, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
CHO Cells
Chromosome Aberrations
Chromosomes / drug effects
Cricetinae
Escherichia coli / drug effects
Female
Heterocyclic Compounds, 1-Ring / toxicity*
Male
Mice
Micronucleus Tests
Mutagenicity Tests
Mutagens*
Salmonella typhimurium / drug effects
Thiones / toxicity*
Chemical
Reg. No./Substance:
0/4-phenyl-1,3-dithia-2-thioxocyclopent-4-ene; 0/Heterocyclic Compounds, 1-Ring; 0/Mutagens; 0/Thiones

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