Document Detail

Mutagenicity testing of steroids obtained from bile acids and cholesterol.
MedLine Citation:
PMID:  6349845     Owner:  NLM     Status:  MEDLINE    
Twenty bile acid or cholesterol derivatives were tested for mutagenicity by the Ames spot test procedure against five Salmonella typhimurium strains in the presence and absence of rat liver microsomes. No strong mutagens were identified, but four of the compounds increased the number of revertant colonies observed. Three of these compounds were selected for dose response experiments using the Ames plate incorporation assay procedure with strain TA 1538. No positive results were obtained. These results suggest that none of the twenty bile acid derivatives tested is likely to be the initiating agent in the aetiology of colon cancer.
C A McKillop; R W Owen; R F Bilton; E A Haslam
Related Documents :
10478825 - Inhibition of eleven mutagens by various tea extracts, (-)epigallocatechin-3-gallate, g...
3566345 - Carcinogenicity of extract of airborne particles using newborn mice and comparative stu...
7038455 - The effects of nitrous acid on the mutagenicity of two coal liquids and their genetical...
11152975 - Effects of mono-, di- and tri-hydroxybenzoic acids on the nitrosation of propranolol: s...
8164475 - Decrease of hypochlorous acid and hydroxyl radical generated by stimulated human neutro...
294825 - Acid phosphatase in leukemic blasts: characterization by isoelectric focusing in polyac...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Carcinogenesis     Volume:  4     ISSN:  0143-3334     ISO Abbreviation:  Carcinogenesis     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1179-83     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Bile Acids and Salts / toxicity*
Cholesterol / analogs & derivatives*,  toxicity
Microsomes, Liver / metabolism
Mutagenicity Tests
Rats, Inbred Strains
Salmonella typhimurium / drug effects
Structure-Activity Relationship
Reg. No./Substance:
0/Bile Acids and Salts; 0/Mutagens; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Blood clearance of radioactively labelled cis-diammine 1,1-cyclobutane dicarboxylate platinum (II) (...
Next Document:  Baker's asthma. Clinical and immunological studies.