| Mutagenicity testing of steroids obtained from bile acids and cholesterol. | |
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MedLine Citation:
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PMID: 6349845 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Twenty bile acid or cholesterol derivatives were tested for mutagenicity by the Ames spot test procedure against five Salmonella typhimurium strains in the presence and absence of rat liver microsomes. No strong mutagens were identified, but four of the compounds increased the number of revertant colonies observed. Three of these compounds were selected for dose response experiments using the Ames plate incorporation assay procedure with strain TA 1538. No positive results were obtained. These results suggest that none of the twenty bile acid derivatives tested is likely to be the initiating agent in the aetiology of colon cancer. |
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Authors:
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C A McKillop; R W Owen; R F Bilton; E A Haslam |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Carcinogenesis Volume: 4 ISSN: 0143-3334 ISO Abbreviation: Carcinogenesis Publication Date: 1983 Sep |
Date Detail:
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Created Date: 1983-10-08 Completed Date: 1983-10-08 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8008055 Medline TA: Carcinogenesis Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1179-83 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Bile Acids and Salts / toxicity* Biotransformation Cholesterol / analogs & derivatives*, toxicity Male Microsomes, Liver / metabolism Mutagenicity Tests Mutagens* Mutation* Rats Rats, Inbred Strains Salmonella typhimurium / drug effects Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Bile Acids and Salts; 0/Mutagens; 57-88-5/Cholesterol |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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