Document Detail


Mutagenicity testing of steroids obtained from bile acids and cholesterol.
MedLine Citation:
PMID:  6349845     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty bile acid or cholesterol derivatives were tested for mutagenicity by the Ames spot test procedure against five Salmonella typhimurium strains in the presence and absence of rat liver microsomes. No strong mutagens were identified, but four of the compounds increased the number of revertant colonies observed. Three of these compounds were selected for dose response experiments using the Ames plate incorporation assay procedure with strain TA 1538. No positive results were obtained. These results suggest that none of the twenty bile acid derivatives tested is likely to be the initiating agent in the aetiology of colon cancer.
Authors:
C A McKillop; R W Owen; R F Bilton; E A Haslam
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Carcinogenesis     Volume:  4     ISSN:  0143-3334     ISO Abbreviation:  Carcinogenesis     Publication Date:  1983 Sep 
Date Detail:
Created Date:  1983-10-08     Completed Date:  1983-10-08     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008055     Medline TA:  Carcinogenesis     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1179-83     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Bile Acids and Salts / toxicity*
Biotransformation
Cholesterol / analogs & derivatives*,  toxicity
Male
Microsomes, Liver / metabolism
Mutagenicity Tests
Mutagens*
Mutation*
Rats
Rats, Inbred Strains
Salmonella typhimurium / drug effects
Structure-Activity Relationship
Chemical
Reg. No./Substance:
0/Bile Acids and Salts; 0/Mutagens; 57-88-5/Cholesterol

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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