| Mutagenicity testing of chlorinated biphenyls and chlorinated dibenzofurans. | |
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MedLine Citation:
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PMID: 7043248 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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4 chlorinated biphenyl and 5 chlorinated dibenzofuran compounds have been evaluated in the reversion assay developed by B.N Ames using Salmonella typhimurium histidine auxotrophs. All these compounds (2,4,2'-4'-tetrachlorobiphenyl, 3,4,3',4'-tetrachlorobiphenyl, 4-chlorobiphenyl, 2,4,,6,2',4',6'-hexachlorobiphenyl, dibenzofuran, 2,9-dichlorodibenzofuran, 3,6-dichlorodibenzofuran, 2,3,7,8-tetrachlorodibenzofuran and octachlorodibenzofuran) were nonmutagenic for strains TA98 and TA100 when tested over a 3-log dose range. They were also not mutagenic whether or not varying concentrations of microsomal extracts (S9) from uninduced rats or from rats induced by several methods were included in the experimental protocol. |
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Authors:
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R Schoeny |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Mutation research Volume: 101 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1982 Mar |
Date Detail:
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Created Date: 1982-07-22 Completed Date: 1982-07-22 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 45-56 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzofurans / pharmacology* Biphenyl Compounds / pharmacology* Hydrocarbons, Chlorinated / pharmacology* Mutagenicity Tests Mutagens* Rats Salmonella typhimurium / genetics |
| Grant Support | |
ID/Acronym/Agency:
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ES 05117-01A1/ES/NIEHS NIH HHS; USPHS00159/SP/CSAP SAMHSA HHS |
| Chemical | |
Reg. No./Substance:
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0/Benzofurans; 0/Biphenyl Compounds; 0/Hydrocarbons, Chlorinated; 0/Mutagens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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