Document Detail


Mutagenicity study of nine monoalkyl phthalates and a dialkyl phthalate using Salmonella typhimurium and Escherichia coli.
MedLine Citation:
PMID:  6339336     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Nine monoalkyl (C1-C8) phthalates and di-(2-ethylhexyl) phthalate (DEHP) were assayed for mutagenicity in two strains of Salmonella typhimurium (TA98 and TA100) and two strains of Escherichia coli WP2 try- (uvrA+ and uvrA-) with and without metabolic activation with S-9 mix. The procedure of Ames et al. (Mutation Res. 1975, 31, 347) was used, with minor modifications. None of the compounds tested showed any mutagenic activity, but all the monoalkyl phthalates showed some lethality towards the S. typhimurium strains, the most toxic being monoheptyl phthalate. A marginally lethal effect on the Salmonella strains was shown by DEHP, but only at the highest concentration tested (2000 micrograms/plate) and in the absence of S-9 mix.
Authors:
K Yoshikawa; A Tanaka; T Yamaha; H Kurata
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  21     ISSN:  0278-6915     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  1983 Apr 
Date Detail:
Created Date:  1983-05-27     Completed Date:  1983-05-27     Revised Date:  2006-03-13    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  221-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Diethylhexyl Phthalate / toxicity
Escherichia coli
Male
Mutagens*
Phthalic Acids / toxicity*
Rats
Rats, Inbred F344
Salmonella typhimurium
Chemical
Reg. No./Substance:
0/Mutagens; 0/Phthalic Acids; 117-81-7/Diethylhexyl Phthalate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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