Document Detail


Mutagenicity studies with N-acetyl-L-aspartic acid.
MedLine Citation:
PMID:  19445994     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Analytical studies have reported that N-acetyl-L-aspartic acid (NAA) is present at low concentrations in many foods. The current studies were conducted to assess the mutagenicity of NAA using standard OECD guideline in vitro bacterial and in vivo mammalian mutagenicity studies. For comparison and control data, mutagenicity studies were also conducted with its constituent amino acid L-aspartate (ASP) because NAA is metabolized to ASP. The combination of an in vitro method for assessing point mutations in bacteria and an in vivo method to assess clastogenicity in an animal model provided adequate evidence for mutagenicity hazard assessment of NAA. No evidence of mutagenicity was observed in either test system with either NAA or ASP. The results from the current studies demonstrate that the presence of NAA in foods is not likely to represent a risk for mutagenicity.
Authors:
Sule Karaman; Abby Myhre; E Maria Donner; Susan M Munley; Bryan Delaney
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Publication Detail:
Type:  Journal Article     Date:  2009-05-13
Journal Detail:
Title:  Food and chemical toxicology : an international journal published for the British Industrial Biological Research Association     Volume:  47     ISSN:  1873-6351     ISO Abbreviation:  Food Chem. Toxicol.     Publication Date:  2009 Aug 
Date Detail:
Created Date:  2009-07-15     Completed Date:  2009-10-19     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8207483     Medline TA:  Food Chem Toxicol     Country:  England    
Other Details:
Languages:  eng     Pagination:  1936-40     Citation Subset:  IM    
Affiliation:
DuPont Company, Toxicology, 2450 SE Oak Tree Ct., Ankeny, IA 50021, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Aspartic Acid / analogs & derivatives*,  toxicity
Bone Marrow / drug effects,  ultrastructure
Escherichia coli / drug effects,  genetics
Mice
Mice, Inbred ICR
Micronucleus Tests
Mutagenicity Tests
Mutagens / toxicity*
Salmonella typhimurium / drug effects,  genetics
Chemical
Reg. No./Substance:
0/Mutagens; 56-84-8/Aspartic Acid; 997-55-7/N-acetylaspartate

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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