| Mutagenicity of some hydroxylaminotoluene derivatives towards Salmonella typhimurium in esterification systems. | |
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MedLine Citation:
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PMID: 3553529 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mutagenicity of 2-hydroxylamino-4-nitrotoluene (2HA4NT), 4-hydroxylamino-2-nitrotoluene (4HA2NT), 2-hydroxylamino-6-nitrotoluene (2HA6NT) or 4-acetylamino-2-hydroxylaminotoluene (4AA2HAT) towards Salmonella typhimurium strains TA98 and TA100 was investigated in the absence and presence of uridine-5'-diphosphoglucuronic acid (UDPGA), acetyl CoA or 3'-phosphoadenosine-5'-phosphosulfate (PAPS) systems, or S9 mix. None of the hydroxylaminonitrotoluenes (2HA4NT, 4HA2NT or 2HA6NT) were mutagenic in both strains while 4AA2HAT was a base-pair substitution mutagen in the UDPGA and PAPS systems. The indirect mutagenic activity was markedly decreased by omission of microsomal fraction (MCF) or UDPGA from the UDPGA system and by addition of beta-glucuronidase to the system. Similarly, the mutagenic activity was markedly decreased either when 105000 X g supernatant fluid (S105), adenosine triphosphate (ATP) or Na2SO4 was omitted from the PAPS system or when pentachlorophenol (PCP) or aryl sulphatase was added to the system. Moreover, the mutagenic activity in either system was markedly decreased by the addition of glutathione (GSH). These results suggested that two esterifications with glucuronic acid and sulfuric acid may play an important role in the appearance of mutagenic activity of 4AA2HAT. |
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Authors:
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M Mori; M Sayama; M Futagami; M Naito; T Miyahara; H Kozuka |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Journal of pharmacobio-dynamics Volume: 9 ISSN: 0386-846X ISO Abbreviation: J. Pharmacobio-dyn. Publication Date: 1986 Dec |
Date Detail:
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Created Date: 1987-06-01 Completed Date: 1987-06-01 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7901854 Medline TA: J Pharmacobiodyn Country: JAPAN |
Other Details:
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Languages: eng Pagination: 1036-9 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Glucuronates / metabolism Glutathione / metabolism Male Microsomes, Liver / metabolism Mutagenicity Tests Mutagens* / metabolism Rats Rats, Inbred Strains Salmonella typhimurium / drug effects Sulfuric Acids / metabolism Toluene / analogs & derivatives, toxicity* |
| Chemical | |
Reg. No./Substance:
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0/Glucuronates; 0/Mutagens; 0/Sulfuric Acids; 108-88-3/Toluene; 70-18-8/Glutathione |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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