Document Detail

Mutagenicity of organic extracts from Canadian drinking water in the Salmonella/mammalian-microsome assay.
MedLine Citation:
PMID:  399917     Owner:  NLM     Status:  MEDLINE    
Organic extracts of chlorinated Ontario drinking water samples have been found to induce mutation and lethality in the Salmonella/mammalian-microsome histadine reversion assay. Collections of water were made at water treatment plants in five municipalities in June 1978. To determine the reproducibility of the positive mutagenic effects found, a second sampling at the same plants was performed in September 1978. Preparation of extracts involved passing 200 liter samples through XAD-2 resin columns which were eluted with a mixture of hexane and acetone, and the eluent was evaporated to dryness. For those extracts with sufficient organic matter, dose-related increases in mutagenicity were observed. Extracts of untreated water from a river and a well were weakly mutagenic.
E R Nestmann; G L LeBel; D T Williams; D J Kowbel
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental mutagenesis     Volume:  1     ISSN:  0192-2521     ISO Abbreviation:  Environ Mutagen     Publication Date:  1979  
Date Detail:
Created Date:  1981-03-17     Completed Date:  1981-03-17     Revised Date:  2000-12-18    
Medline Journal Info:
Nlm Unique ID:  7909737     Medline TA:  Environ Mutagen     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  337-45     Citation Subset:  IM    
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MeSH Terms
Dose-Response Relationship, Drug
Mutagenicity Tests
Salmonella typhimurium / genetics
Water Pollutants / analysis*
Water Pollutants, Chemical / analysis*
Water Supply / analysis*
Reg. No./Substance:
0/Mutagens; 0/Water Pollutants; 0/Water Pollutants, Chemical

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