| Mutagenicity of lichen constituents. | |
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MedLine Citation:
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PMID: 6236972 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Usnic acid (the most abundant lichen constituents), physodic, and physodalic acids isolated from Hypogymnia enteromorph (Ach.) Nyl. were tested for mutagenicity in the Ames Salmonella/microsome assay. Physodalic acid exhibited clear dose-related mutagenicity against Salmonella typhimurium strain TA 100 with or without S9 mix in both plate-incorporation and preincubation assays. The addition of S9 mix increased the number of revertants approximately threefold and fourfold in preincubation and plate-incorporation assays, respectively. |
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Authors:
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T Shibamoto; C I Wei |
Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Environmental mutagenesis Volume: 6 ISSN: 0192-2521 ISO Abbreviation: Environ Mutagen Publication Date: 1984 |
Date Detail:
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Created Date: 1984-11-16 Completed Date: 1984-11-16 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7909737 Medline TA: Environ Mutagen Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 757-62 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Benzofurans / isolation & purification, toxicity* Dibenzoxepins / isolation & purification, toxicity* Lichens* Mutagenicity Tests Mutagens / toxicity* Mutation* Salmonella typhimurium / drug effects Structure-Activity Relationship |
| Chemical | |
Reg. No./Substance:
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0/Benzofurans; 0/Dibenzoxepins; 0/Mutagens; 84-24-2/physodic acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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