Document Detail

Mutagenicity of lichen constituents.
MedLine Citation:
PMID:  6236972     Owner:  NLM     Status:  MEDLINE    
Usnic acid (the most abundant lichen constituents), physodic, and physodalic acids isolated from Hypogymnia enteromorph (Ach.) Nyl. were tested for mutagenicity in the Ames Salmonella/microsome assay. Physodalic acid exhibited clear dose-related mutagenicity against Salmonella typhimurium strain TA 100 with or without S9 mix in both plate-incorporation and preincubation assays. The addition of S9 mix increased the number of revertants approximately threefold and fourfold in preincubation and plate-incorporation assays, respectively.
T Shibamoto; C I Wei
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Environmental mutagenesis     Volume:  6     ISSN:  0192-2521     ISO Abbreviation:  Environ Mutagen     Publication Date:  1984  
Date Detail:
Created Date:  1984-11-16     Completed Date:  1984-11-16     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7909737     Medline TA:  Environ Mutagen     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  757-62     Citation Subset:  IM    
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MeSH Terms
Benzofurans / isolation & purification,  toxicity*
Dibenzoxepins / isolation & purification,  toxicity*
Mutagenicity Tests
Mutagens / toxicity*
Salmonella typhimurium / drug effects
Structure-Activity Relationship
Reg. No./Substance:
0/Benzofurans; 0/Dibenzoxepins; 0/Mutagens; 84-24-2/physodic acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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