Document Detail

Mutagenicity of inhaled anesthetics in Drosophila melanogaster.
MedLine Citation:
PMID:  2858171     Owner:  NLM     Status:  MEDLINE    
The mutagenic effects of several inhaled anesthetic agents were investigated using the sex-linked recessive lethal assay in the fruit fly, Drosophila melanogaster. Male wild-type flies were exposed for 1 hr to either halothane, enflurane, isoflurane, or fluroxene at vapor concentrations of 1 or 2% or to nitrous oxide at concentrations of 40 or 80%. Control flies were exposed to air alone. Following treatment, male flies were mated with untreated virgin females of the Basc strain and the rate of sex-linked recessive lethals was determined in the F2 generation. Halothane and fluroxene produced a dose-dependent and statistically significant increase in the rate of sex-linked recessive lethals, whereas enflurane, isoflurane, and nitrous oxide were not mutagenic at the concentrations tested.
Y R Kundomal; J M Baden
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.    
Journal Detail:
Title:  Anesthesiology     Volume:  62     ISSN:  0003-3022     ISO Abbreviation:  Anesthesiology     Publication Date:  1985 Mar 
Date Detail:
Created Date:  1985-04-12     Completed Date:  1985-04-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  1300217     Medline TA:  Anesthesiology     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  305-9     Citation Subset:  AIM; IM    
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MeSH Terms
Anesthesia, Inhalation*
Anesthetics / toxicity*
Drosophila melanogaster
Enflurane / toxicity
Ethers / toxicity
Genes, Lethal / drug effects
Genes, Recessive / drug effects
Halothane / toxicity
Isoflurane / toxicity
Mutagenicity Tests / methods
Nitrous Oxide / toxicity
Reg. No./Substance:
0/Anesthetics; 0/Ethers; 0/Mutagens; 10024-97-2/Nitrous Oxide; 13838-16-9/Enflurane; 151-67-7/Halothane; 26675-46-7/Isoflurane

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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