| Mutagenicity of inhaled anesthetics in Drosophila melanogaster. | |
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MedLine Citation:
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PMID: 2858171 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The mutagenic effects of several inhaled anesthetic agents were investigated using the sex-linked recessive lethal assay in the fruit fly, Drosophila melanogaster. Male wild-type flies were exposed for 1 hr to either halothane, enflurane, isoflurane, or fluroxene at vapor concentrations of 1 or 2% or to nitrous oxide at concentrations of 40 or 80%. Control flies were exposed to air alone. Following treatment, male flies were mated with untreated virgin females of the Basc strain and the rate of sex-linked recessive lethals was determined in the F2 generation. Halothane and fluroxene produced a dose-dependent and statistically significant increase in the rate of sex-linked recessive lethals, whereas enflurane, isoflurane, and nitrous oxide were not mutagenic at the concentrations tested. |
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Authors:
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Y R Kundomal; J M Baden |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S. |
Journal Detail:
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Title: Anesthesiology Volume: 62 ISSN: 0003-3022 ISO Abbreviation: Anesthesiology Publication Date: 1985 Mar |
Date Detail:
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Created Date: 1985-04-12 Completed Date: 1985-04-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 1300217 Medline TA: Anesthesiology Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 305-9 Citation Subset: AIM; IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Anesthesia, Inhalation* Anesthetics / toxicity* Animals Drosophila melanogaster Enflurane / toxicity Ethers / toxicity Genes, Lethal / drug effects Genes, Recessive / drug effects Halothane / toxicity Isoflurane / toxicity Male Mutagenicity Tests / methods Mutagens* Nitrous Oxide / toxicity |
| Chemical | |
Reg. No./Substance:
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0/Anesthetics; 0/Ethers; 0/Mutagens; 10024-97-2/Nitrous Oxide; 13838-16-9/Enflurane; 151-67-7/Halothane; 26675-46-7/Isoflurane |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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