| Mutagenicity of hydrazides of pyrimidine-nucleotide-precursors in the Salmonella-oxygenase test. | |
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MedLine Citation:
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PMID: 6406044 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Five newly synthesized hydrazides: L-aspartic acid dihydrazide, DL-ureido-succinic acid dihydrazide, DL-dihydroorotic acid hydrazide, orotic acid hydrazide, and 2,2'-anhydro-1-(beta-D-arabinofuranosyl)-orotic acid hydrazide were tested for mutagenicity in the Ames test. All these hydrazides except DL-ureidosuccinic acid dihydrazide were found to be non-mutagenic. The mutagenic activities of the latter compound which causes base-pair substitution was decreased in the presence of metabolic activator. |
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Authors:
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E Golovinsky; K Norpoth; E Stankevich; E Mohtashamipur |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cancer letters Volume: 19 ISSN: 0304-3835 ISO Abbreviation: Cancer Lett. Publication Date: 1983 May |
Date Detail:
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Created Date: 1983-07-29 Completed Date: 1983-07-29 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7600053 Medline TA: Cancer Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 67-72 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Antimetabolites / pharmacology Aspartic Acid / analogs & derivatives, pharmacology Base Composition / drug effects Dose-Response Relationship, Drug Hydrazines / pharmacology* Male Mice Mutagenicity Tests Salmonella typhimurium / drug effects |
| Chemical | |
Reg. No./Substance:
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0/Antimetabolites; 0/Hydrazines; 37458-18-7/ureidosuccinic acid dihydrazide; 56-84-8/Aspartic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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