Document Detail


Mutagenicity of hydrazides of pyrimidine-nucleotide-precursors in the Salmonella-oxygenase test.
MedLine Citation:
PMID:  6406044     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Five newly synthesized hydrazides: L-aspartic acid dihydrazide, DL-ureido-succinic acid dihydrazide, DL-dihydroorotic acid hydrazide, orotic acid hydrazide, and 2,2'-anhydro-1-(beta-D-arabinofuranosyl)-orotic acid hydrazide were tested for mutagenicity in the Ames test. All these hydrazides except DL-ureidosuccinic acid dihydrazide were found to be non-mutagenic. The mutagenic activities of the latter compound which causes base-pair substitution was decreased in the presence of metabolic activator.
Authors:
E Golovinsky; K Norpoth; E Stankevich; E Mohtashamipur
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer letters     Volume:  19     ISSN:  0304-3835     ISO Abbreviation:  Cancer Lett.     Publication Date:  1983 May 
Date Detail:
Created Date:  1983-07-29     Completed Date:  1983-07-29     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  7600053     Medline TA:  Cancer Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  67-72     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antimetabolites / pharmacology
Aspartic Acid / analogs & derivatives,  pharmacology
Base Composition / drug effects
Dose-Response Relationship, Drug
Hydrazines / pharmacology*
Male
Mice
Mutagenicity Tests
Salmonella typhimurium / drug effects
Chemical
Reg. No./Substance:
0/Antimetabolites; 0/Hydrazines; 37458-18-7/ureidosuccinic acid dihydrazide; 56-84-8/Aspartic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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