| Mutagenicity of glycerol chlorohydrines and of their esters with higher fatty acids present in protein hydrolysates. | |
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MedLine Citation:
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PMID: 7035914 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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3-chloro-1,2-propanediol and 1,3-dichloro-2-propanol caused base substitutions in Salmonella typhimurium TA1535 both with and without metabolic activation. Metabolic activation seemed to act mainly by decreasing the toxicity of these compounds. A difference in the growth of the wild-type and repair-deficient strains of Escherichia coli was observed only for 1,3-dichloro-2-propanol with S9 mix. Esters of both chlorohydrines with fatty acids has smaller mutagenic effects than unesterified compounds. |
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Authors:
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L Silhánková; F Smíd; M Cerná; J Davídek; J Velísek |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Mutation research Volume: 103 ISSN: 0027-5107 ISO Abbreviation: Mutat. Res. Publication Date: 1982 Jan |
Date Detail:
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Created Date: 1982-04-20 Completed Date: 1982-04-20 Revised Date: 2003-11-14 |
Medline Journal Info:
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Nlm Unique ID: 0400763 Medline TA: Mutat Res Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 77-81 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biotransformation Chlorohydrins / pharmacology* Dose-Response Relationship, Drug Escherichia coli / drug effects Esters / pharmacology Male Mice Mice, Inbred C57BL Microsomes, Liver / metabolism Mutagenicity Tests Mutagens* Mutation Protein Hydrolysates* Salmonella typhimurium / drug effects Structure-Activity Relationship alpha-Chlorohydrin / analogs & derivatives, pharmacology |
| Chemical | |
Reg. No./Substance:
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0/Chlorohydrins; 0/Esters; 0/Mutagens; 0/Protein Hydrolysates; 96-23-1/1,3-dichloro-2-propanol; 96-24-2/alpha-Chlorohydrin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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