Document Detail

Mutagenicity of glycerol chlorohydrines and of their esters with higher fatty acids present in protein hydrolysates.
MedLine Citation:
PMID:  7035914     Owner:  NLM     Status:  MEDLINE    
3-chloro-1,2-propanediol and 1,3-dichloro-2-propanol caused base substitutions in Salmonella typhimurium TA1535 both with and without metabolic activation. Metabolic activation seemed to act mainly by decreasing the toxicity of these compounds. A difference in the growth of the wild-type and repair-deficient strains of Escherichia coli was observed only for 1,3-dichloro-2-propanol with S9 mix. Esters of both chlorohydrines with fatty acids has smaller mutagenic effects than unesterified compounds.
L Silhánková; F Smíd; M Cerná; J Davídek; J Velísek
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Mutation research     Volume:  103     ISSN:  0027-5107     ISO Abbreviation:  Mutat. Res.     Publication Date:  1982 Jan 
Date Detail:
Created Date:  1982-04-20     Completed Date:  1982-04-20     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0400763     Medline TA:  Mutat Res     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  77-81     Citation Subset:  IM    
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MeSH Terms
Chlorohydrins / pharmacology*
Dose-Response Relationship, Drug
Escherichia coli / drug effects
Esters / pharmacology
Mice, Inbred C57BL
Microsomes, Liver / metabolism
Mutagenicity Tests
Protein Hydrolysates*
Salmonella typhimurium / drug effects
Structure-Activity Relationship
alpha-Chlorohydrin / analogs & derivatives,  pharmacology
Reg. No./Substance:
0/Chlorohydrins; 0/Esters; 0/Mutagens; 0/Protein Hydrolysates; 96-23-1/1,3-dichloro-2-propanol; 96-24-2/alpha-Chlorohydrin

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